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Background <p>Disseminated disease by the fungi <i>Scedosporium</i> is rare in immunocompetent patients and has not been reported in the context of severe SARS-CoV-2 infection.</p> Case presentation <p>A retired, 41-year-old police officer with a history of obesity and arterial hypertensionpresented to the emergency department with acute respiratory hypoxemic failure due to severe SARS-CoV-2 pneumonia. He had no history of intravenous drug use and was HIV negative. He practised home aquarium care, biking, river swimming, and fishing. He reported no recent travel to the sea, lakes, or caves.[JG1] He required prolonged mechanical ventilation and had several documented episodes of ventilator-associated pneumonia due to <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae, </i>which later evolved to necrotizing pneumonia, multiple lung abscesses, bronchopleural fistula, empyema and subpleural abscess. Despite sedation withdrawal, he remained unconscious; a brain MRI revealed multiple brain abscesses. <i>Scedosporium boydii</i> (<i>S. boydii</i>) grew on lung and brain abscess cultures. In addition to percutaneous drainage of lung abscesses, he was treated with combined therapy with voriconazole and liposomal amphotericin B, considering a possible synergic effect. Drainage of the multiple brain abscesses was not feasible; thus, radiological progression was documented, leading to the patient´s demise despite five weeks of treatment. [JG1]Revisor 1: The abstract is generally well-written, but I suggest omitting the mention of the patient's hobbies asthis detail is not pertinent to the clinical case being discussed. The abstract should be concise and focused solely on the critical clinical aspects.</p> Conclusion <p>Invasive fungal infections (IFIs) by molds are an emerging condition in patients with COVID-19. Cases of aspergillosis, candidiasis and mucormycosis were increasingly reported during the COVID-19 pandemic. This is the first report of a fatal disseminated infection due to <i>Scedosporium boydii </i>preceded by a severe SARS CoV-2 infection.</p>

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Scedosporium Boydii disseminated infection complicating severe SARS-CoV-2 infection in an immunocompetent patient: a case report

  • 期刊论文

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  • 发表日期：

    2025年10月31日

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  • Adriana M. Trejos Tenorio,
  • Daniel Montoya Roldán,
  • Alicia I. Hidrón Botero

摘要

Background

Disseminated disease by the fungi Scedosporium is rare in immunocompetent patients and has not been reported in the context of severe SARS-CoV-2 infection.

Case presentation

A retired, 41-year-old police officer with a history of obesity and arterial hypertensionpresented to the emergency department with acute respiratory hypoxemic failure due to severe SARS-CoV-2 pneumonia. He had no history of intravenous drug use and was HIV negative. He practised home aquarium care, biking, river swimming, and fishing. He reported no recent travel to the sea, lakes, or caves.[JG1] He required prolonged mechanical ventilation and had several documented episodes of ventilator-associated pneumonia due to Pseudomonas aeruginosa and Klebsiella pneumoniae, which later evolved to necrotizing pneumonia, multiple lung abscesses, bronchopleural fistula, empyema and subpleural abscess. Despite sedation withdrawal, he remained unconscious; a brain MRI revealed multiple brain abscesses. Scedosporium boydii (S. boydii) grew on lung and brain abscess cultures. In addition to percutaneous drainage of lung abscesses, he was treated with combined therapy with voriconazole and liposomal amphotericin B, considering a possible synergic effect. Drainage of the multiple brain abscesses was not feasible; thus, radiological progression was documented, leading to the patient´s demise despite five weeks of treatment. [JG1]Revisor 1: The abstract is generally well-written, but I suggest omitting the mention of the patient's hobbies asthis detail is not pertinent to the clinical case being discussed. The abstract should be concise and focused solely on the critical clinical aspects.

Conclusion

Invasive fungal infections (IFIs) by molds are an emerging condition in patients with COVID-19. Cases of aspergillosis, candidiasis and mucormycosis were increasingly reported during the COVID-19 pandemic. This is the first report of a fatal disseminated infection due to Scedosporium boydii preceded by a severe SARS CoV-2 infection.