Scholarlink

<p>The global emergence of antibiotic resistance in <i>Neisseria gonorrhoeae</i> (NG) infections poses a critical public health challenge. This study aimed to evaluate global resistance rates to extended-spectrum cephalosporins (ESCs) in <i>N. gonorrhoeae</i>, considering factors such as time, geography, antimicrobial susceptibility testing (AST), and resistance interpretation. A systematic review and meta-analysis (from 1988 to 2025) of 252 studies from 71 countries reported a weighted pooled resistance rate (WPR) of ≤ 2.5% for ESCs. Significant temporal variation in ESCs-resistant isolates (<i>P</i> &lt; 0.05) underscores the dynamic nature of resistance development. Significantly, there was a difference in penicillin resistance rates between countries/ continents, and AST (<i>P</i> &lt; 0.001). These findings emphasize the urgent need for effective antimicrobial stewardship, enhanced contact tracing, and comprehensive monitoring systems to combat antimicrobial resistance in gonococcal infections.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Temporal and geographic trends in extended-spectrum cephalosporins resistance among Neisseria gonorrhoeae isolates worldwide: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月29日

查看全文
  • Laith B. Alhusseini,
  • Bita Hasani,
  • Firas Nabeeh Jaafar,
  • Masoumeh Beig,
  • Sara Abbasian,
  • Khalil Azizian

摘要

The global emergence of antibiotic resistance in Neisseria gonorrhoeae (NG) infections poses a critical public health challenge. This study aimed to evaluate global resistance rates to extended-spectrum cephalosporins (ESCs) in N. gonorrhoeae, considering factors such as time, geography, antimicrobial susceptibility testing (AST), and resistance interpretation. A systematic review and meta-analysis (from 1988 to 2025) of 252 studies from 71 countries reported a weighted pooled resistance rate (WPR) of ≤ 2.5% for ESCs. Significant temporal variation in ESCs-resistant isolates (P < 0.05) underscores the dynamic nature of resistance development. Significantly, there was a difference in penicillin resistance rates between countries/ continents, and AST (P < 0.001). These findings emphasize the urgent need for effective antimicrobial stewardship, enhanced contact tracing, and comprehensive monitoring systems to combat antimicrobial resistance in gonococcal infections.