Scholarlink

Background <p>Bacterial-associated bloodstream infections (BSIs) pose a significant health challenge, particularly in low- and middle-income countries where diagnostic delays and antimicrobial resistance exacerbate outcomes. This study investigated the prevalence, clinical correlates, bacterial aetiology, and resistance profiles of BSIs among hospitalised febrile patients in Lagos, Nigeria.</p> Methods <p>A total of 2,940 blood samples were collected from febrile inpatients across five healthcare centres between 2018 and 2023. Standard microbiological techniques and mass spectrometry were employed for bacterial identification. Antimicrobial susceptibility testing was performed following CLSI guidelines. Statistical analyses included chi-square tests, regression modelling, and correlation analysis.</p> Results <p>Of the 2,940 samples, 307 (10.44%) were culture-positive, with gram-negative bacteria accounting for 91.8% of isolates. <i>Proteus spp.</i>, <i>Escherichia coli</i>, and <i>Klebsiella spp.</i> were the most prevalent pathogens. Septicaemia, bradycardia, and extreme age groups (0–10, ≥ 41&#xa0;years) were significantly associated with BSIs (<i>p</i> &lt; 0.0001). Multidrug resistance was highest in <i>P. vulgaris</i> (32.7%) and <i>E. coli</i> (27.9%). A strong correlation (<i>R</i> = 0.76) was observed between clinical diagnosis and culture positivity.</p> Conclusion <p>The findings reveal a high burden of gram-negative bloodstream infections predominantly caused by <i>Proteus spp.</i>, <i>E. coli</i>, and <i>Klebsiella spp.</i>, with significant multidrug resistance, particularly in <i>P. vulgaris</i> and <i>E. coli</i>, and strong associations with septicaemia, bradycardia, extreme age groups, and clinical diagnoses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bacterial-associated bloodstream infections among hospitalized patients in Lagos, Nigeria

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月1日

查看全文
  • Christopher Oladimeji Fakorede,
  • Kehinde O. Amisu,
  • Kabiru Olusegun Akinyemi

摘要

Background

Bacterial-associated bloodstream infections (BSIs) pose a significant health challenge, particularly in low- and middle-income countries where diagnostic delays and antimicrobial resistance exacerbate outcomes. This study investigated the prevalence, clinical correlates, bacterial aetiology, and resistance profiles of BSIs among hospitalised febrile patients in Lagos, Nigeria.

Methods

A total of 2,940 blood samples were collected from febrile inpatients across five healthcare centres between 2018 and 2023. Standard microbiological techniques and mass spectrometry were employed for bacterial identification. Antimicrobial susceptibility testing was performed following CLSI guidelines. Statistical analyses included chi-square tests, regression modelling, and correlation analysis.

Results

Of the 2,940 samples, 307 (10.44%) were culture-positive, with gram-negative bacteria accounting for 91.8% of isolates. Proteus spp., Escherichia coli, and Klebsiella spp. were the most prevalent pathogens. Septicaemia, bradycardia, and extreme age groups (0–10, ≥ 41 years) were significantly associated with BSIs (p < 0.0001). Multidrug resistance was highest in P. vulgaris (32.7%) and E. coli (27.9%). A strong correlation (R = 0.76) was observed between clinical diagnosis and culture positivity.

Conclusion

The findings reveal a high burden of gram-negative bloodstream infections predominantly caused by Proteus spp., E. coli, and Klebsiella spp., with significant multidrug resistance, particularly in P. vulgaris and E. coli, and strong associations with septicaemia, bradycardia, extreme age groups, and clinical diagnoses.