Scholarlink

Background <p>The frequency of clinical isolation of non-tuberculous mycobacteria (NTM) in patients with multidrug-resistant or rifampin-resistant tuberculosis (MDR/RR-TB) is increasing, but its relevance remains unclear. This study aimed to assess the frequency of NTM isolation and its clinical relevance in respiratory specimens from MDR/RR-TB patients in Wenzhou, China.</p> Methods <p>Medical records of MDR/RR-TB patients with NTM isolated from 2014 to 2022 were reviewed retrospectively. To establish the clinical relevance, the diagnostic criteria for nontuberculous mycobacterial pulmonary disease (NTM-PD) published by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) were applied.</p> Results <p>Between 2014 and 2022, a total of 922 patients were enrolled, among whom 45 (4.9%) cases yielded NTM isolates, resulting in the isolation of 68 distinct NTM strains. The most prevalent NTM species was <i>M. abscessus</i>, accounting for 36.8% (25/68) of the isolates, followed by <i>M. intracellulare</i> at 22.1% (15/68) and <i>M. avium</i> at 8.8% (6/68). Notably, only five cases (0.54%) met the microbiologic criteria specified in the ATS/IDSA guidelines. Four of these cases received no specific NTM treatment and achieved a favorable prognosis with anti-TB therapy. Remarkably, a single case out of 922 (0.11%) was identified as having concomitant MDR/RR-TB and NTM-PD.</p> Conclusions <p>The clinical relevance of respiratory NTM isolates in patients with MDR/RR-TB is generally low, with the overwhelming majority of these NTM isolates being either colonizers or contaminants. Consequently, in most cases, those with concomitant NTM isolates do not require specific therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Negligible clinical impact of subsequent non-tuberculous mycobacteria isolation during MDR/RR-TB treatment: a 9-year retrospective cohort study from Wenzhou, China

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月24日

查看全文
  • Qingyong Zheng,
  • Quelu Chen,
  • Wenzhen Zhou,
  • Ouyang Huang,
  • Guiqing He

摘要

Background

The frequency of clinical isolation of non-tuberculous mycobacteria (NTM) in patients with multidrug-resistant or rifampin-resistant tuberculosis (MDR/RR-TB) is increasing, but its relevance remains unclear. This study aimed to assess the frequency of NTM isolation and its clinical relevance in respiratory specimens from MDR/RR-TB patients in Wenzhou, China.

Methods

Medical records of MDR/RR-TB patients with NTM isolated from 2014 to 2022 were reviewed retrospectively. To establish the clinical relevance, the diagnostic criteria for nontuberculous mycobacterial pulmonary disease (NTM-PD) published by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) were applied.

Results

Between 2014 and 2022, a total of 922 patients were enrolled, among whom 45 (4.9%) cases yielded NTM isolates, resulting in the isolation of 68 distinct NTM strains. The most prevalent NTM species was M. abscessus, accounting for 36.8% (25/68) of the isolates, followed by M. intracellulare at 22.1% (15/68) and M. avium at 8.8% (6/68). Notably, only five cases (0.54%) met the microbiologic criteria specified in the ATS/IDSA guidelines. Four of these cases received no specific NTM treatment and achieved a favorable prognosis with anti-TB therapy. Remarkably, a single case out of 922 (0.11%) was identified as having concomitant MDR/RR-TB and NTM-PD.

Conclusions

The clinical relevance of respiratory NTM isolates in patients with MDR/RR-TB is generally low, with the overwhelming majority of these NTM isolates being either colonizers or contaminants. Consequently, in most cases, those with concomitant NTM isolates do not require specific therapy.