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Background <p><i>Salmonella</i> and <i>Shigella</i> are a critical concern of the developing world and responsible for the high rate of diarrhea-related deaths. The treatment of these infections remains a challenge, due to the global rise in broad-spectrum resistance to many antibiotics. The aim of this study to determine the prevalence, antimicrobial susceptibility patterns, and associated factors of <i>Salmonella</i> and <i>Shigella</i> among under five children with diarrhea attending Bule Hora University Teaching Hospital, Bule Hora, West Guji, Ethiopia.</p> Methods <p>A hospital-based cross-sectional study was conducted from July 01 to October 30, 2023. Three hundred sixty-five under five children with diarrhea were enrolled consecutively using convenient sampling technique. Data about patient socio-demographics, signs, and symptoms was obtained from the parents/guardians of each child using a questionnaire. Stool specimens from diarrheic children were collected and processed for isolation of <i>Salmonella</i> and <i>Shigella</i> using standard bacteriological methods. Antibiotic susceptibility patterns were determined by using the Kirby Bauer disc diffusion method. Data analysis was performed by using SPSS version 25. A <i>p</i>-value &lt; 0.05 at 95% CI was considered statistically significant.</p> Results <p>The prevalence of <i>salmonella</i> and <i>Shigella</i> isolates were 6.3% (23/365) and 4.9% (18/365) respectively. The isolates were 95.1% susceptible to ciprofloxacin and 73.2% to ceftriaxone. The isolates were 39.02% multidrug resistance to classes of drug choice for susceptibility tests. Presence of vomiting (AOR = 2.36), contact with diarrhoeal patient (AOR = 3.38), untrimmed fingernail (AOR = 5.20), storing cooked food in open containers (AOR = 6.5), unimproved source of drinking water from well and river (AOR = 3.86 &amp; 3.2) showed statistically significant association with <i>Salmonella</i> and <i>Shigella</i> infections.</p> Conclusion <p>The prevalence of <i>Salmonella</i> and <i>Shigella</i> isolates were relatively high in the study area. The isolates were found to be sensitive to Ceftriaxone, ciprofloxacin, and cotrimoxazole; and could be possible antimicrobial choices of infection. Contact with diarrhoeal patients, untrimmed fingernails, storing cooked food in open containers and unimproved sources of drinking water were the main sources of infection. Therefore, to alleviate this infection, culture based bacterial species identification and promoting antibiotics sensitivity-based treatment are strongly recommended to avoid empirical treatment in the study area.</p>

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Prevalence, antimicrobial susceptibility pattern and associated factors of Salmonella and Shigella among under five children with diarrhea attending Bule Hora University Teaching Hospital, Bule Hora, West Guji, Ethiopia

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  • 发表日期：

    2025年4月21日

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  • Yadeta Dade,
  • Moorthy Kannaiyan,
  • Wako Dedecha,
  • Derese Daka,
  • Oliyad Husen,
  • Tibeso Gemechu,
  • Alqeer Aliyo,
  • Kalicha Boru

摘要

Background

Salmonella and Shigella are a critical concern of the developing world and responsible for the high rate of diarrhea-related deaths. The treatment of these infections remains a challenge, due to the global rise in broad-spectrum resistance to many antibiotics. The aim of this study to determine the prevalence, antimicrobial susceptibility patterns, and associated factors of Salmonella and Shigella among under five children with diarrhea attending Bule Hora University Teaching Hospital, Bule Hora, West Guji, Ethiopia.

Methods

A hospital-based cross-sectional study was conducted from July 01 to October 30, 2023. Three hundred sixty-five under five children with diarrhea were enrolled consecutively using convenient sampling technique. Data about patient socio-demographics, signs, and symptoms was obtained from the parents/guardians of each child using a questionnaire. Stool specimens from diarrheic children were collected and processed for isolation of Salmonella and Shigella using standard bacteriological methods. Antibiotic susceptibility patterns were determined by using the Kirby Bauer disc diffusion method. Data analysis was performed by using SPSS version 25. A p-value < 0.05 at 95% CI was considered statistically significant.

Results

The prevalence of salmonella and Shigella isolates were 6.3% (23/365) and 4.9% (18/365) respectively. The isolates were 95.1% susceptible to ciprofloxacin and 73.2% to ceftriaxone. The isolates were 39.02% multidrug resistance to classes of drug choice for susceptibility tests. Presence of vomiting (AOR = 2.36), contact with diarrhoeal patient (AOR = 3.38), untrimmed fingernail (AOR = 5.20), storing cooked food in open containers (AOR = 6.5), unimproved source of drinking water from well and river (AOR = 3.86 & 3.2) showed statistically significant association with Salmonella and Shigella infections.

Conclusion

The prevalence of Salmonella and Shigella isolates were relatively high in the study area. The isolates were found to be sensitive to Ceftriaxone, ciprofloxacin, and cotrimoxazole; and could be possible antimicrobial choices of infection. Contact with diarrhoeal patients, untrimmed fingernails, storing cooked food in open containers and unimproved sources of drinking water were the main sources of infection. Therefore, to alleviate this infection, culture based bacterial species identification and promoting antibiotics sensitivity-based treatment are strongly recommended to avoid empirical treatment in the study area.