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<p>Bacterial meningitis is a severe infectious disease. Study of bacterial meningitis of children in recent years are limited. It is unclear whether there have been any changes in the epidemiological characteristics of bacterial meningitis during the years of the COVID-19 pandemic. The purpose of this study was to describe a large, nationwide study of bacterial meningitis in China. We analyzed data of hospitalized patients with bacterial meningitis from 30 hospitals in China from 2016—2021. A total of 16566&#xa0;episodes of bacterial meningitis were included, of which 13614&#xa0;episodes (82.18%) occurred in children age under 5-years old. The admission proportion of bacterial meningitis to total hospitalization decreased from 0.24%&#xa0;to 0.16% after COVID -19 pandemic (under COVID -Zero Strategy) (<i>P</i> &lt; .0001). The risk of at least one complication was 26.45% (4382/16566). The three most common complications were hydrocephalus (2351, 14.19%), subdural effusions or empyema (1438, 8.68%), and seizures (794, 4.79%). Ninety-one (0.55%) patients died in hospital. Risks of complications and mortality (0.55%) were related to age under 5&#xa0;years old (<i>P</i> &lt; .0001). The median length of stay and inpatient expenditures for children with bacterial meningitis were 16&#xa0;days and 2,697.38 USD.</p><p><b>Conclusions</b></p><p>Bacterial meningitis mostly occurred in children aged &lt; 5 y. The percentage of 30 tertiary hospitalized children with bacterial meningitis apparently decreased after the COVID-19 pandemic. Ninety-one (0.55%) patients died in the hospital.</p>

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Epidemiological characteristics and disease burden of bacterial meningitis in hospitalized children in China: a 6-year nationwide retrospective study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月24日

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  • Linlin Liu,
  • Xinyu Wang,
  • Lingyun Guo,
  • Tianming Chen,
  • Bing Hu,
  • Binglin Jian,
  • Guoshuang Feng,
  • Yueping Zeng,
  • Gang Liu

摘要

Bacterial meningitis is a severe infectious disease. Study of bacterial meningitis of children in recent years are limited. It is unclear whether there have been any changes in the epidemiological characteristics of bacterial meningitis during the years of the COVID-19 pandemic. The purpose of this study was to describe a large, nationwide study of bacterial meningitis in China. We analyzed data of hospitalized patients with bacterial meningitis from 30 hospitals in China from 2016—2021. A total of 16566 episodes of bacterial meningitis were included, of which 13614 episodes (82.18%) occurred in children age under 5-years old. The admission proportion of bacterial meningitis to total hospitalization decreased from 0.24% to 0.16% after COVID -19 pandemic (under COVID -Zero Strategy) (P < .0001). The risk of at least one complication was 26.45% (4382/16566). The three most common complications were hydrocephalus (2351, 14.19%), subdural effusions or empyema (1438, 8.68%), and seizures (794, 4.79%). Ninety-one (0.55%) patients died in hospital. Risks of complications and mortality (0.55%) were related to age under 5 years old (P < .0001). The median length of stay and inpatient expenditures for children with bacterial meningitis were 16 days and 2,697.38 USD.

Conclusions

Bacterial meningitis mostly occurred in children aged < 5 y. The percentage of 30 tertiary hospitalized children with bacterial meningitis apparently decreased after the COVID-19 pandemic. Ninety-one (0.55%) patients died in the hospital.