Scholarlink

Background <p>Early diagnosis of invasive aspergillosis (IA) can significantly enhance patient survival rates; however, accurately diagnosing IA remains a formidable challenge. Lateral flow device (LFD), as a non-invasive detection method, have been extensively investigated in numerous clinical studies. The objective of this study was to elucidate the diagnostic accuracy of LFD in detecting IA through a meta-analysis.</p> Methods <p>The PubMed, Embase, and Web of Science database were searched to obtain clinical studies on the diagnosis of IA by LFD. A random-effects meta-analysis with a bivariate hierarchical model was used, the estimates and 95% confidence intervals (CI) were used to present pooled sensitivity, specificity, and summary receiver operating characteristic curves (SROC).</p> Results <p>Twenty-five cohort or case-control studies were included. The pooled sensitivity of LFD in the diagnosis of IA was 0.67 (95% CI: 0.57–0.75), specificity was 0.90 (95% CI: 0.85–0.93), diagnostic odds ratio was 15.70 (95% CI: 9.69–25.44), the area under the SROC curve (AUC) was 0.87 (95% CI: 0.82–0.93). Subgroup analysis showed that the sensitivity of bronchoalveolar lavage fluid specimen was higher than serum specimen (0.72, 95% CI: 0.67–0.78 vs. 0.49, 95% CI: 0.41–0.56), bronchoalveolar lavage fluid specimens also have higher diagnostic accuracy (AUC = 0.89).</p> Conclusions <p>LFD is an effective technique for the detection of IA infection, but attention should be paid to the influence of specimen source on the accuracy of this technique.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Lateral-flow device for the diagnosis of invasive aspergillosis: a systematic review and diagnostic meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月20日

查看全文
  • Yuqing Fan,
  • Xue Shang,
  • Yan Wang,
  • Yinghua zhang,
  • Xiuxia Li,
  • Kehu Yang,
  • Haidi Lv,
  • Kangle Guo

摘要

Background

Early diagnosis of invasive aspergillosis (IA) can significantly enhance patient survival rates; however, accurately diagnosing IA remains a formidable challenge. Lateral flow device (LFD), as a non-invasive detection method, have been extensively investigated in numerous clinical studies. The objective of this study was to elucidate the diagnostic accuracy of LFD in detecting IA through a meta-analysis.

Methods

The PubMed, Embase, and Web of Science database were searched to obtain clinical studies on the diagnosis of IA by LFD. A random-effects meta-analysis with a bivariate hierarchical model was used, the estimates and 95% confidence intervals (CI) were used to present pooled sensitivity, specificity, and summary receiver operating characteristic curves (SROC).

Results

Twenty-five cohort or case-control studies were included. The pooled sensitivity of LFD in the diagnosis of IA was 0.67 (95% CI: 0.57–0.75), specificity was 0.90 (95% CI: 0.85–0.93), diagnostic odds ratio was 15.70 (95% CI: 9.69–25.44), the area under the SROC curve (AUC) was 0.87 (95% CI: 0.82–0.93). Subgroup analysis showed that the sensitivity of bronchoalveolar lavage fluid specimen was higher than serum specimen (0.72, 95% CI: 0.67–0.78 vs. 0.49, 95% CI: 0.41–0.56), bronchoalveolar lavage fluid specimens also have higher diagnostic accuracy (AUC = 0.89).

Conclusions

LFD is an effective technique for the detection of IA infection, but attention should be paid to the influence of specimen source on the accuracy of this technique.