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Background <p>Opportunistic infections (OIs) in patients with advanced HIV disease remain a serious health issue, particularly in low-and middle-income countries.</p> Objectives <p>This study aims to describe the clinical characteristics and factors associated with mortality among hospitalized advanced HIV-infected men who have sex with men (MSM).</p> Methods <p>A prospective cross-sectional study was conducted at the Hospital for Tropical Diseases in Ho Chi Minh City between March and June 2023. Data was collected through interviews and medical record reviews. A multivariate logistic regression model was employed to assess factors associated with hospitalization outcomes, with statistical significance set at <i>p</i> &lt; 0.05.</p> Results <p>The study included 121 participants, with 61.3% aged 25–34 years and 42.2% classified as underweight. Only 35.5% of patients received OI preventive treatment. Comorbidities were noted as follows: hepatitis B (12.4%), hepatitis C (2.5%), and syphilis (43.8%). A total of 41.3% of patients had at least one OI, with <i>Mycobacterium tuberculosis</i> being the most common (46.3%), followed by <i>Pneumocystis jirovecii</i> pneumonia (44.6%) and <i>Cryptococcus neoformans</i> (19%). Sepsis was present in 20.7% of patients. The in-hospital mortality rate was 19%. Factors significantly associated with mortality included being underweight, HBV coinfection, <i>C. neoformans</i> infection, lack of OI preventive treatment, and sepsis.</p> Conclusion <p>The study reveals a high inpatient mortality rate among advanced HIV-infected MSM, even among relatively young patients. Increased mortality was associated with being underweight, having sepsis, HBV coinfection, <i>C. neoformans</i> infection, and not receiving OI preventive treatment.</p>

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Clinical characteristics and treatment outcomes of opportunistic infections in advanced HIV disease patients among men who have sex with men in Vietnam: A prospective cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月25日

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  • Ly Trieu Vo,
  • Dung Quoc Phan,
  • Phi Hoang Nguyen,
  • Araba Gyan,
  • Nhut Minh Vuong,
  • Tung Nhu Le Nguyen,
  • Lan Y Vo,
  • Giao Huynh

摘要

Background

Opportunistic infections (OIs) in patients with advanced HIV disease remain a serious health issue, particularly in low-and middle-income countries.

Objectives

This study aims to describe the clinical characteristics and factors associated with mortality among hospitalized advanced HIV-infected men who have sex with men (MSM).

Methods

A prospective cross-sectional study was conducted at the Hospital for Tropical Diseases in Ho Chi Minh City between March and June 2023. Data was collected through interviews and medical record reviews. A multivariate logistic regression model was employed to assess factors associated with hospitalization outcomes, with statistical significance set at p < 0.05.

Results

The study included 121 participants, with 61.3% aged 25–34 years and 42.2% classified as underweight. Only 35.5% of patients received OI preventive treatment. Comorbidities were noted as follows: hepatitis B (12.4%), hepatitis C (2.5%), and syphilis (43.8%). A total of 41.3% of patients had at least one OI, with Mycobacterium tuberculosis being the most common (46.3%), followed by Pneumocystis jirovecii pneumonia (44.6%) and Cryptococcus neoformans (19%). Sepsis was present in 20.7% of patients. The in-hospital mortality rate was 19%. Factors significantly associated with mortality included being underweight, HBV coinfection, C. neoformans infection, lack of OI preventive treatment, and sepsis.

Conclusion

The study reveals a high inpatient mortality rate among advanced HIV-infected MSM, even among relatively young patients. Increased mortality was associated with being underweight, having sepsis, HBV coinfection, C. neoformans infection, and not receiving OI preventive treatment.