Objective <p>To construct a combined model based on the CT and clinical characteristics of acquired immune deficiency syndrome (AIDS) with infection of <i>Talaromyces marneffei</i> (TM) and evaluate the diagnostic efficacy of the combined model.</p> Methods <p>A retrospective analysis was conducted on 225 patients with AIDS patients with pulmonary infection admitted to the Shanghai Public Health Clinical Center from February 2012 to October 2022. Based on the final microbiological test results, they were divided into a group infected with TM and a group not infected with TM. Univariate and multivariate analyses were conducted on the lung CT imaging and clinical characteristics of these 225 patients. A nomogram was used to construct a combined model, and a calibration plot was drawn to test the diagnostic efficacy of the combined model.</p> Results <p>Multivariate logistic regression analysis showed that fever, rash, elevated PLT, elevated Hb, CD4⁺T lymphocyte count &lt; 50/ul, and lung CT histology features including diffuse punctate and nodular shadows, mass-like consolidation, consolidation shadows, single or multiple lung abscesses or cyst shadows, and pleural effusion were independent risk factors for the diagnosis of AIDS with TM infection (<i>P</i> &lt; 0.05). The construction of a joint model using nomogram and calibration plot showed that the constructed joint model had a high degree of fit.</p> Conclusion <p>The combined model constructed in this study has certain clinical value for evaluating whether AIDS co-infection is caused by TM.</p> Clinical trial <p>Not applicable.</p>