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<p><i>Bilophila wadsworthia</i> is rarely found in the bloodstream. We report the first case of bloodstream infection caused by <i>B. wadsworthia</i> in a diabetic foot patient in China. <i>B. wadsworthia</i> is a normal component of the human intestinal microbiota, and a history of diarrhea may contribute to its translocation into the bloodstream. Due to the slow growth of <i>B. wadsworthia</i>, prolonged incubation was essential for its detection. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) enabled rapid identification of the pathogen. Early initiation of Piperacillin/Tazobactam therapy resulted in a favorable clinical outcome.</p>

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First case report of bacteremia caused by Bilophila wadsworthia in China, and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月5日

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  • Fangrong Gan,
  • Shuang Luo,
  • Xiaoxun Wei,
  • Shuguang Zuo

摘要

Bilophila wadsworthia is rarely found in the bloodstream. We report the first case of bloodstream infection caused by B. wadsworthia in a diabetic foot patient in China. B. wadsworthia is a normal component of the human intestinal microbiota, and a history of diarrhea may contribute to its translocation into the bloodstream. Due to the slow growth of B. wadsworthia, prolonged incubation was essential for its detection. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) enabled rapid identification of the pathogen. Early initiation of Piperacillin/Tazobactam therapy resulted in a favorable clinical outcome.