Personality and neuropsychiatric symptoms in individuals diagnosed with long COVID

This study investigates persistent physical and neuropsychiatric symptoms in Long COVID, focusing on their severity and assessing risk/resilience factors, including conscientiousness and neuroticism. The study utilizes a mediation model to explore the potential role of psychological distress in mediating its impact on cognitive decline.

In an online survey, 114 participants diagnosed with Long COVID completed assessments, including the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) for psychological distress, Subjective Cognitive Decline (SCD) questionnaire for cognitive decline, Pittsburgh Sleep Quality Index (PSQI) for sleep disorders, and Multidimensional Scale of Perceived Social Support (MSPSS) with “BIG-5 inventory” subscales for risk/resilience factors.

Findings showed high rates of depressive disorders (45.6%), generalized anxiety disorders (21%), sleep disturbances (76.3%), and reported cognitive changes (94.7%). Conscientiousness negatively correlated with psychological distress (p < .001, r = − .48) and cognitive decline (p < .001, r = − .36), while neuroticism positively correlated (p < .001, r = .62 and p < .001, r = .41, respectively). Social support negatively correlated with psychological distress (p < .001, r = − .52) and cognitive decline (p < .001, r = − .41). Psychological distress fully mediated personality traits and cognitive decline correlations, with significant full mediation for neuroticism [95% CI = (0.22, 0.48)] and conscientiousness [95% CI = (-0.33, -0.07)], controlling for age, gender, other chronic morbidity and social support.

The study underscores the significance of incorporating psychological interventions into treatment plans to alleviate distress symptoms associated with cognitive decline in conditions like Long COVID.