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Infectious disease events in people with HIV receiving kidney transplantation: Analysis of the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年10月11日

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  • Katharina Kusejko,
  • Roger D. Kouyos,
  • Enos Bernasconi,
  • Katia Boggian,
  • Dominique L. Braun,
  • Alexandra Calmy,
  • Matthias Cavassini,
  • Christian van Delden,
  • Hansjakob Furrer,
  • Christian Garzoni,
  • Hans H. Hirsch,
  • Cedric Hirzel,
  • Oriol Manuel,
  • Patrick Schmid,
  • Nina Khanna,
  • Fadi Haidar,
  • Marco Bonani,
  • Dela Golshayan,
  • Michael Dickenmann,
  • Daniel Sidler,
  • Aurelia Schnyder,
  • Nicolas J. Mueller,
  • Huldrych F. Günthard,
  • Peter W. Schreiber

摘要

Background

Since the implementation of universal antiretroviral therapy, kidney transplantation (K-Tx) has become a valuable option for treatment of end-stage kidney disease for people with HIV (PWH) with similar patient and graft survival as compared to HIV-uninfected patients. Little is known about the hazards and manifestations of infectious disease (ID) events occurring in kidney transplant recipients with HIV.

Methods

Using linked information collected in the Swiss HIV Cohort Study (SHCS) and the Swiss Transplant Cohort Study (STCS), we described in-depth demographical and clinical characteristics of PWH who received a K-Tx since 2008. Further, we performed recurrent time to event analyses to understand whether HIV was an independent risk factor for ID events.

Results

Overall, 24 PWH with 57 ID events were included in this study (100% match of SHCS to STCS). Of these, 17 (70.8%) patients had at least one ID event: 22 (38.6%) viral (HIV not counted), 18 (31.6%) bacterial, one (1.8%) fungal and 16 (28.1%) probable infections. Most ID events affected the respiratory tract (25, 37.3%) or the urinary tract (13, 19.4%). Pathogen types and infection sites were similar in PWH and a matched control group of HIV-uninfected patients. HIV was not an independent risk factor for ID events (adjusted hazard ratio 0.94, p = 0.9).

Conclusion

By linking data from two large national Swiss cohorts, we provided in-depth information on ID events in PWH receiving a K-Tx in Switzerland. HIV infection was not associated with an increased hazard for ID events after K-Tx.