Scholarlink

Background <p>Cognitive aging poses a major worldwide health concern. The association between basal metabolic rate (BMR) and cognition isn’t well understood. This research examines sarcopenia’s potential role as a mediator: linking BMR to cognitive function.</p> Methods <p>Analysis used China Health and Retirement Longitudinal Study (CHARLS) data from adults aged ≥ 60 years (2015, 2018 waves). Mental integrity and episodic memory recall assessed cognitive function. Linear multivariate analyses were conducted to examine the associations between BMR, sarcopenia, and cognitive function, adjusting for potential confounders. Mediation analyses explored sarcopenia’s role in the BMR-cognitive function relationship. Restricted cubic splines assessed nonlinear relationships, and subgroup analyses evaluated group heterogeneity.</p> Results <p>Longitudinal linear multivariate modeling, after covariate adjustment, demonstrated a significant positive association linking BMR to cognitive function (β = 1.23, 95% CI: 0.25–2.21, <i>P</i> = 0.014). Sarcopenia showed an inverse relationship with cognitive function (β = − 0.75, 95% CI: −1.11– −0.40, <i>P</i> &lt; 0.001). Critically, sarcopenia mediated 26.98% of BMR’s total effect on cognitive function, with an indirect effect of 5.27 × 10⁻⁴ (95% CI: 8.61 × 10⁻⁴– 1.54 × 10⁻³). Subgroup analysis indicated that smoking status and place of residence had significant effects on the relationship between basal metabolic rate and cognitive function.</p> Conclusions <p>The study found that BMR is positively associated with cognitive function, whereas sarcopenia is inversely associated with cognitive function and mediates the BMR- cognitive function association.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between basal metabolic rate and cognitive function in Chinese older adults: the mediating effect of sarcopenia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月16日

查看全文
  • Hong Ding,
  • Lei Zhang,
  • Chao Ma,
  • Zhizi Shao,
  • Xiaojiang Zhao,
  • Changqing Li

摘要

Background

Cognitive aging poses a major worldwide health concern. The association between basal metabolic rate (BMR) and cognition isn’t well understood. This research examines sarcopenia’s potential role as a mediator: linking BMR to cognitive function.

Methods

Analysis used China Health and Retirement Longitudinal Study (CHARLS) data from adults aged ≥ 60 years (2015, 2018 waves). Mental integrity and episodic memory recall assessed cognitive function. Linear multivariate analyses were conducted to examine the associations between BMR, sarcopenia, and cognitive function, adjusting for potential confounders. Mediation analyses explored sarcopenia’s role in the BMR-cognitive function relationship. Restricted cubic splines assessed nonlinear relationships, and subgroup analyses evaluated group heterogeneity.

Results

Longitudinal linear multivariate modeling, after covariate adjustment, demonstrated a significant positive association linking BMR to cognitive function (β = 1.23, 95% CI: 0.25–2.21, P = 0.014). Sarcopenia showed an inverse relationship with cognitive function (β = − 0.75, 95% CI: −1.11– −0.40, P < 0.001). Critically, sarcopenia mediated 26.98% of BMR’s total effect on cognitive function, with an indirect effect of 5.27 × 10⁻⁴ (95% CI: 8.61 × 10⁻⁴– 1.54 × 10⁻³). Subgroup analysis indicated that smoking status and place of residence had significant effects on the relationship between basal metabolic rate and cognitive function.

Conclusions

The study found that BMR is positively associated with cognitive function, whereas sarcopenia is inversely associated with cognitive function and mediates the BMR- cognitive function association.