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Background <p>Improving medication safety implies patient-centred multidisciplinary cooperation. During the hospital stay for an acute care episode, the patient needs a comprehensive management to guarantee the best possible outcome.</p> Methods <p>The study was designed as a non-blinded, multicentre stepped-wedge cluster randomised clinical trial, taking place in six French University Hospitals.</p> <p>Each cluster began with the control period in which standard care did not include pharmaceutical intervention. Every 14-day period, one hospital unit was electronically randomised to switch to the intervention period until all cluster groups received the intervention, which consisted of collaborative pharmaceutical care (CPC) associating medication reconciliation at hospital admission, pharmaceutical analysis of the medication order, medication review and collaborative meeting.</p> <p>The primary outcome was assessing the intervention through the rate of patients with at least one medication error (ME) on the admission medication order (such as omission, wrong dose or wrong route of administration), comparing the two periods.</p> Results <p>CPC decreased the rate of patients with at least one ME from 88.9% (n = 243) to 29.2% (n = 267) (<i>p</i> &lt; 0.0001). A total of 1817 MEs were discovered, of which 1121 (61.7%) were in the control period and 696 (38.3%) in the intervention period before resolution by the CPC. After resolving 567 of them, 129 medication errors still remained after CPC. So, a median of 3 MEs [IQR = 1;6] per patient were detected in the control period vs 0 [IQR = 0;1] after CPC in the intervention period (<i>p</i> &lt; 0.0001). Patients were 21-times more likely to avoid a ME with CPC (OR: 20.8 [8.3;52.2], <i>p</i> &lt; 0.0001). The rate of patients with a 2–3 critical ME level decreased from 70.8% to 12.0% in the control vs intervention periods respectively (OR: 18.4 [7.7;43.9], <i>p</i> &lt; 0.0001).</p> Conclusions <p>CPC can prevent the occurrence of MEs and thus can improve inpatients’ medication management and safety. Pharmacists play a key role in combating medication-related harm in healthcare settings.</p> Trial registration <p>This study is registered on ClinicalTrials.gov with the reference number NCT02598115 (2015–11–04).</p>

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Impact of collaborative pharmaceutical care on older inpatients’ medication safety: multicentre stepped-wedge cluster randomised trial (MEDREV Study)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月11日

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  • Géraldine Leguelinel-Blache,
  • Sophie Bouvet,
  • Pierrick Bedouch,
  • Bérengère Bachelet,
  • Catherine Chenailler,
  • Thomas Dantin,
  • Laure Geneletti,
  • Alexia Janes,
  • Florence Scher,
  • Bogdan Cireașă,
  • Jean-Marie Kinowski,
  • Christel Castelli,
  • Clarisse Roux-Marson,
  • Pierrick Bedouch,
  • Magali Bourdelin,
  • Bruno Charpiat,
  • Ornella Cornort,
  • Julien Gravoulet,
  • Audrey Janoly-Dumenil,
  • Michel Juste,
  • Céline Mongaret,
  • Benoit Allenet,
  • Valéry Antoine,
  • Véronique Battaglia,
  • Olivier Cannizzo,
  • Didier Carrie,
  • Philippe Cestac,
  • Fiona Chautant,
  • Chloé Choukroun,
  • Rémy Collomp,
  • Pascal Couturier,
  • Armelle Develay-Rambourg,
  • Perrine Foessel,
  • Prudence Gibert,
  • Bernard Goichot,
  • Bénédicte Gourieux,
  • Anne Jantzen,
  • Emmanuelle Lambert-Kuhn,
  • Hervé Lefebvre,
  • Constance Loue,
  • Stéphanie Lucas-Daver,
  • Claire Monpagens,
  • Christelle Mouchoux,
  • Danith Ok,
  • Sandra Paul,
  • Mathilde Pradier,
  • Agathe Prieto,
  • Charlotte Rouzaud-Laborde,
  • Hélène Richard,
  • Mathilde Strumia,
  • Marina Taurel,
  • Rémi Varin,
  • Maud Vives,
  • Catherine Weber

摘要

Background

Improving medication safety implies patient-centred multidisciplinary cooperation. During the hospital stay for an acute care episode, the patient needs a comprehensive management to guarantee the best possible outcome.

Methods

The study was designed as a non-blinded, multicentre stepped-wedge cluster randomised clinical trial, taking place in six French University Hospitals.

Each cluster began with the control period in which standard care did not include pharmaceutical intervention. Every 14-day period, one hospital unit was electronically randomised to switch to the intervention period until all cluster groups received the intervention, which consisted of collaborative pharmaceutical care (CPC) associating medication reconciliation at hospital admission, pharmaceutical analysis of the medication order, medication review and collaborative meeting.

The primary outcome was assessing the intervention through the rate of patients with at least one medication error (ME) on the admission medication order (such as omission, wrong dose or wrong route of administration), comparing the two periods.

Results

CPC decreased the rate of patients with at least one ME from 88.9% (n = 243) to 29.2% (n = 267) (p < 0.0001). A total of 1817 MEs were discovered, of which 1121 (61.7%) were in the control period and 696 (38.3%) in the intervention period before resolution by the CPC. After resolving 567 of them, 129 medication errors still remained after CPC. So, a median of 3 MEs [IQR = 1;6] per patient were detected in the control period vs 0 [IQR = 0;1] after CPC in the intervention period (p < 0.0001). Patients were 21-times more likely to avoid a ME with CPC (OR: 20.8 [8.3;52.2], p < 0.0001). The rate of patients with a 2–3 critical ME level decreased from 70.8% to 12.0% in the control vs intervention periods respectively (OR: 18.4 [7.7;43.9], p < 0.0001).

Conclusions

CPC can prevent the occurrence of MEs and thus can improve inpatients’ medication management and safety. Pharmacists play a key role in combating medication-related harm in healthcare settings.

Trial registration

This study is registered on ClinicalTrials.gov with the reference number NCT02598115 (2015–11–04).