Background <p>While the care of the stoma poses a problem for individuals, the presence of complications, lack of stoma adjustment, and impaired quality of life can be more exhausting for patients, as well.</p> Methods <p>This thesis study was designed and conducted as a multicenter, randomised controlled intervention study with repetitive measurements in a pretest-posttest order. Patients, who underwent intestinal stoma in 5 hospitals, (one of which was private), in a city in the south-eastern Turkey between 20 March and December 31, 2021, participated in the study. Seventy-four patients, who were regarded eligible, were randomised and divided into experimental and control groups. A patient information form, the Stoma Complications Evaluation Form, the Stoma-Related Problems Form, the Ostomy Adjustment Inventory-23, and the Stoma Quality of Life Scale were used to collect data.</p> Results <p>Results of the study revealed a significant difference between the groups based on quality of life and stoma adjustment.</p> Conclusions <p>The nurse navigation programme not only increases the quality of life and stoma adjustment in patients with stoma but also reduces stoma complications.</p> Trial registration <p>ClinicalTrials.gov NCT05809661 (Registered: 30/03/2023). Retrospectively registered.</p>