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<p>Intracholecystic papillary neoplasm (ICPN) is a rare premalignant lesion of the gallbladder, and its natural history remains incompletely understood. We report a case of ICPN presenting as a small gallbladder polyp with progressive growth. A 56-year-old woman was found to have a gallbladder polyp measuring 7.6&#xa0;mm, which increased to 11.2&#xa0;mm over 2 years and 8 months. Contrast-enhanced computed tomography demonstrated a papillary lesion with enhancement. Laparoscopic cholecystectomy was performed. Histopathological examination revealed pyloric gland-type ICPN with low-grade dysplasia without invasive carcinoma. Immunohistochemical analysis showed positivity for MUC6 and MUC5AC, supporting gastric-type differentiation. No recurrence has been observed during postoperative follow-up.</p><p>This case suggests that progressive growth, papillary morphology, and enhancement characteristics may indicate neoplastic potential even in gallbladder polyps initially measuring &lt; 10&#xa0;mm, suggesting the importance of careful follow-up and timely surgical intervention.</p>

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Progressive growth of a small gallbladder polyp diagnosed as intracholecystic papillary neoplasm: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Yusaku Yokotani,
  • Yuki Nakahata,
  • Haruka Okuyama,
  • Rieko Mukai,
  • Junji Nagano,
  • Naoyuki Sakamoto,
  • Akihiro Obora,
  • Yoshiki Murakami,
  • Takao Kojima,
  • Nobuaki Yagi

摘要

Intracholecystic papillary neoplasm (ICPN) is a rare premalignant lesion of the gallbladder, and its natural history remains incompletely understood. We report a case of ICPN presenting as a small gallbladder polyp with progressive growth. A 56-year-old woman was found to have a gallbladder polyp measuring 7.6 mm, which increased to 11.2 mm over 2 years and 8 months. Contrast-enhanced computed tomography demonstrated a papillary lesion with enhancement. Laparoscopic cholecystectomy was performed. Histopathological examination revealed pyloric gland-type ICPN with low-grade dysplasia without invasive carcinoma. Immunohistochemical analysis showed positivity for MUC6 and MUC5AC, supporting gastric-type differentiation. No recurrence has been observed during postoperative follow-up.

This case suggests that progressive growth, papillary morphology, and enhancement characteristics may indicate neoplastic potential even in gallbladder polyps initially measuring < 10 mm, suggesting the importance of careful follow-up and timely surgical intervention.