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Background <p>Steatotic liver disease (SLD) is a chronic condition associated with cardiometabolic risk. The body roundness index (BRI) is a novel visceral adiposity marker. We evaluate the associations between BRI and risks of SLD, major adverse liver-related outcomes (MALO), liver-related mortality, and all-cause mortality using the UK Biobank cohort.</p> Methods <p>Data from 399,115 participants (aged 37–73 years) without baseline SLD or MALO were analyzed. BRI was categorized into sex-specific quartiles. Outcomes were identified via national health records. Adjusted hazard ratios (HRs) were estimated using Fine–Gray competing risk models and Cox proportional hazards models.</p> Results <p>During a median follow-up of 13.9 years, the incidence of SLD, MALO, liver-related mortality, and all-cause mortality was 1.38%, 1.25%, 0.24%, and 8.31%, respectively. Higher BRI was significantly associated with increased SLD risk (HR 6.20; 95% CI 5.28–7.28), with a more pronounced association in women (HR 9.11) than in men (HR 3.38). Significant non-linear, J-shaped associations were observed for SLD and all-cause mortality (both p for nonlinearity &lt; 0.001). Conversely, MALO and liver-related mortality showed linear positive associations (p for nonlinearity &gt; 0.05), with significant risks primarily observed in the highest BRI quartiles.</p> Conclusion <p>Higher BRI is significantly associated with increased risks of SLD, MALO, and bothliver-related and all-cause mortality. These findings suggest that BRI is a valuable tool for identifying individuals at risk of adverse hepatic outcomes, potentially offering predictive utility beyond conventional anthropometric indices.</p>

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Associations of body roundness index with steatotic liver disease and mortality from the UK biobank cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Jinyoung Shin,
  • Seok-Jae Heo,
  • Yae-Ji Lee,
  • Yu-Jin Kwon,
  • Ji-Won Lee

摘要

Background

Steatotic liver disease (SLD) is a chronic condition associated with cardiometabolic risk. The body roundness index (BRI) is a novel visceral adiposity marker. We evaluate the associations between BRI and risks of SLD, major adverse liver-related outcomes (MALO), liver-related mortality, and all-cause mortality using the UK Biobank cohort.

Methods

Data from 399,115 participants (aged 37–73 years) without baseline SLD or MALO were analyzed. BRI was categorized into sex-specific quartiles. Outcomes were identified via national health records. Adjusted hazard ratios (HRs) were estimated using Fine–Gray competing risk models and Cox proportional hazards models.

Results

During a median follow-up of 13.9 years, the incidence of SLD, MALO, liver-related mortality, and all-cause mortality was 1.38%, 1.25%, 0.24%, and 8.31%, respectively. Higher BRI was significantly associated with increased SLD risk (HR 6.20; 95% CI 5.28–7.28), with a more pronounced association in women (HR 9.11) than in men (HR 3.38). Significant non-linear, J-shaped associations were observed for SLD and all-cause mortality (both p for nonlinearity < 0.001). Conversely, MALO and liver-related mortality showed linear positive associations (p for nonlinearity > 0.05), with significant risks primarily observed in the highest BRI quartiles.

Conclusion

Higher BRI is significantly associated with increased risks of SLD, MALO, and bothliver-related and all-cause mortality. These findings suggest that BRI is a valuable tool for identifying individuals at risk of adverse hepatic outcomes, potentially offering predictive utility beyond conventional anthropometric indices.