Scholarlink

Objective <p>Although gastric secretory dysfunction is common in&#xa0;<i>H.pylori</i>-associated gastropathy, the precise mechanisms underlying these functional alterations across different <i>H.pylori</i> antibody subtypes remain incompletely elucidated. This cross-sectional clinical observational study aimed to systematically investigate the associations between specific <i>H.pylori</i> antibody subtype infection status and multiple gastric functional parameters, thereby elucidating potential differences in their impact on gastric secretory function.</p> Methods <p>A total of 2,618 patients were included in this analysis. Serum levels of pepsinogen I (PGI), pepsinogen II (PGII), the PGI/PGII ratio (PGR), gastrin-17 (G-17), and&#xa0;<i>H.pylori</i>&#xa0;antibody subtypes were measured. A cross-sectional study design was employed to analyze baseline characteristics and serological data.</p> Results <p>Compared to the <i>H.pylori</i>-positive group, the <i>H.pylori</i>-negative group demonstrated significantly higher PGI (<i>P</i> = 0.020) and PGR (<i>P</i> &lt; 0.001) levels, while PGII levels were markedly lower (<i>P</i> &lt; 0.001). In the <i>H.pylori</i> subtype analysis, both <i>H.pylori</i>(I) and <i>H.pylori</i>(II) groups exhibited elevated PGII levels compared to the negative group, whereas PGR showed a progressive decreasing trend: <i>H.pylori</i>(I) &lt; <i>H.pylori</i>(II) &lt; <i>H.pylori</i>(-) (<i>P</i> &lt; 0.001). Furthermore, both infected groups had significantly higher G-17 levels than the <i>H.pylori</i>(-) group (all <i>P</i> &lt; 0.001). Males showed higher PGI levels in the infected groups, while in the <i>H.pylori</i>(-) group, multiple parameters (PGII, PGI, G-17) were elevated in males compared to females (<i>P</i> &lt; 0.05). Patients aged ≤ 60&#xa0;years had lower PGI and PGII levels but higher PGR (<i>P</i> &lt; 0.05). Correlation analysis further indicated that G-17 was positively correlated with PGII and negatively correlated with PGR (<i>P</i> &lt; 0.05).</p> Conclusions <p><i>H.pylori</i> infection characteristically alters gastric functional serum markers in a virulence-dependent manner. These patterns biologically reflect the continuous pathological process from gastric mucosal inflammation to atrophy. Our findings underscore the clinical relevance of integrating <i>H.pylori</i> subtyping with gastric function assessment in gastric cancer risk screening, providing a novel perspective for the precise identification of high-risk individuals.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Differential impacts of Helicobacter pylori antibody typing on gastric secretory function: a cross-sectional study based on serum biomarkers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月26日

查看全文
  • Hongyuan Xu,
  • Chenliu Zhu,
  • Yang Yang,
  • Xueping Zhao,
  • Xiaotian Chen,
  • Guangshi Zhong,
  • Xue Liang,
  • Chengning Yang

摘要

Objective

Although gastric secretory dysfunction is common in H.pylori-associated gastropathy, the precise mechanisms underlying these functional alterations across different H.pylori antibody subtypes remain incompletely elucidated. This cross-sectional clinical observational study aimed to systematically investigate the associations between specific H.pylori antibody subtype infection status and multiple gastric functional parameters, thereby elucidating potential differences in their impact on gastric secretory function.

Methods

A total of 2,618 patients were included in this analysis. Serum levels of pepsinogen I (PGI), pepsinogen II (PGII), the PGI/PGII ratio (PGR), gastrin-17 (G-17), and H.pylori antibody subtypes were measured. A cross-sectional study design was employed to analyze baseline characteristics and serological data.

Results

Compared to the H.pylori-positive group, the H.pylori-negative group demonstrated significantly higher PGI (P = 0.020) and PGR (P < 0.001) levels, while PGII levels were markedly lower (P < 0.001). In the H.pylori subtype analysis, both H.pylori(I) and H.pylori(II) groups exhibited elevated PGII levels compared to the negative group, whereas PGR showed a progressive decreasing trend: H.pylori(I) < H.pylori(II) < H.pylori(-) (P < 0.001). Furthermore, both infected groups had significantly higher G-17 levels than the H.pylori(-) group (all P < 0.001). Males showed higher PGI levels in the infected groups, while in the H.pylori(-) group, multiple parameters (PGII, PGI, G-17) were elevated in males compared to females (P < 0.05). Patients aged ≤ 60 years had lower PGI and PGII levels but higher PGR (P < 0.05). Correlation analysis further indicated that G-17 was positively correlated with PGII and negatively correlated with PGR (P < 0.05).

Conclusions

H.pylori infection characteristically alters gastric functional serum markers in a virulence-dependent manner. These patterns biologically reflect the continuous pathological process from gastric mucosal inflammation to atrophy. Our findings underscore the clinical relevance of integrating H.pylori subtyping with gastric function assessment in gastric cancer risk screening, providing a novel perspective for the precise identification of high-risk individuals.