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Objective <p>To investigate the incidence of colorectal polyps in patients with chronic hepatitis B (CHB) complicated by non - alcoholic fatty liver disease (NAFLD) and its risk factors.</p> Methods <p>A total of 505 patients who underwent electronic colonoscopy at The Tianjin Second People’s Hospital from October 2018 to November 2023 and met the inclusion criteria were selected as the research subjects. They were divided into the CHB group, the NAFLD group, and the CHB + NAFLD group. Chi-square test, analysis of variance, and Kruskal Wallis rank sum test were used to compare the characteristics of the three groups of patients. Univariate and multivariate logistic regression were used to evaluate the risk factors for colorectal polyps in patients in the CHB + NAFLD group.</p> Results <p>(1) The detection rate of polyps in the NAFLD group was 73.9%, in the CHB + NAFLD group was 64.2%, and in the CHB group was 48.4%, with a statistically significant difference (<i>P</i> &lt; 0.05). (2) There were statistically significant differences among the three groups in terms of sex, BMI, CAP, history of hypertension, ALT, GGT, ALB, FPG, TG, TC, TBA, UA, HDL, LDL, WBC, RBC, HGB, PLT, PT, and CA19-9(<i>P</i> &lt; 0.05). (3) The CHB + NAFLD group mainly had multiple polyps (58.8%), most of the polyps were small, with polyps ≤ 0.5&#xa0;cm accounting for 68.7%, and the proportion of polyps located in the distal colon was 40.5%. (4) In the comparison of inflammatory polyps among groups, detection rate of the NAFLD group was 9.8%, the CHB + NAFLD group was 5.3%, and the CHB group was 1.1%, with a statistically significant difference (<i>P</i> &lt; 0.05).(5)Age(OR = 1.047,95%CI:1.016 ~ 1.080),diabetes(OR = 3.732,95%CI:1.044 ~ 13.335),WBC(OR = 1.272,95%CI:1.043 ~ 1.552) were independently associated with colorectal polyps development in the CHB + NAFLD group.</p> Conclusion <p>More than half of the patients with CHB complicated by NAFLD can be detected with colorectal polyps. Age, diabetes, WBC were independently associated with colorectal polyps development in this group of people. Colonoscopy screening should be actively carried out for CHB patients complicated by NAFLD.</p>

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Analysis of the incidence and risk factors of colorectal polyps in patients with chronic hepatitis B complicated by non - alcoholic fatty liver disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月3日

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  • Lin Ma,
  • Wen-wen Zheng,
  • Yan Zhang,
  • Wei Wei,
  • Ying Zhao,
  • Xiao-jiang Zhang,
  • Peng-yu Pan,
  • Jian-zhou Li,
  • Zhan-hong Li,
  • Qing-ping Wang,
  • Chun-yan Wang

摘要

Objective

To investigate the incidence of colorectal polyps in patients with chronic hepatitis B (CHB) complicated by non - alcoholic fatty liver disease (NAFLD) and its risk factors.

Methods

A total of 505 patients who underwent electronic colonoscopy at The Tianjin Second People’s Hospital from October 2018 to November 2023 and met the inclusion criteria were selected as the research subjects. They were divided into the CHB group, the NAFLD group, and the CHB + NAFLD group. Chi-square test, analysis of variance, and Kruskal Wallis rank sum test were used to compare the characteristics of the three groups of patients. Univariate and multivariate logistic regression were used to evaluate the risk factors for colorectal polyps in patients in the CHB + NAFLD group.

Results

(1) The detection rate of polyps in the NAFLD group was 73.9%, in the CHB + NAFLD group was 64.2%, and in the CHB group was 48.4%, with a statistically significant difference (P < 0.05). (2) There were statistically significant differences among the three groups in terms of sex, BMI, CAP, history of hypertension, ALT, GGT, ALB, FPG, TG, TC, TBA, UA, HDL, LDL, WBC, RBC, HGB, PLT, PT, and CA19-9(P < 0.05). (3) The CHB + NAFLD group mainly had multiple polyps (58.8%), most of the polyps were small, with polyps ≤ 0.5 cm accounting for 68.7%, and the proportion of polyps located in the distal colon was 40.5%. (4) In the comparison of inflammatory polyps among groups, detection rate of the NAFLD group was 9.8%, the CHB + NAFLD group was 5.3%, and the CHB group was 1.1%, with a statistically significant difference (P < 0.05).(5)Age(OR = 1.047,95%CI:1.016 ~ 1.080),diabetes(OR = 3.732,95%CI:1.044 ~ 13.335),WBC(OR = 1.272,95%CI:1.043 ~ 1.552) were independently associated with colorectal polyps development in the CHB + NAFLD group.

Conclusion

More than half of the patients with CHB complicated by NAFLD can be detected with colorectal polyps. Age, diabetes, WBC were independently associated with colorectal polyps development in this group of people. Colonoscopy screening should be actively carried out for CHB patients complicated by NAFLD.