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Objective <p>The aim of this study was to investigate the validity of DAOH-90 in a contemporary cohort of electively operated patients with colorectal cancer and explore its relationship with postoperative outcomes.</p> Design <p>The study was a retrospective, observational cohort study.</p> Settings <p>Data on patients operated from April 2014 to April 2019 were collected from the Danish Colorectal Cancer Group database and enriched by information from the Danish National Patient Register. DAOH-90 was analyzed by quantile regression for the 10th, 25th, 50th, 75th, and 90th percentile, using Mann-Whitney U-test, and association between DAOH-90 and 1-and 5-year mortality was analyzed using a Cox regression.</p> Patients <p>A total of 16,183 patients with colorectal cancer were included. Median DAOH-90 was 85 (IQR: 82–87). The 90-day mortality was 2.2%.</p> Main outcome measures <p>The primary outcome was the association between DAOH-90 quantiles and long-term mortality (1 and 5 years).</p> Results <p>There was significant association between DAOH-90 in the 25th, 50th and 75th quantile and death between 90 and 365 days (<i>p</i> = 0.0008-&lt; 0.0001), and for death between 1 and 5 years (<i>p</i> = 0.0026-<i>p</i> &lt; 0.0001). Both medical and surgical complications were associated with significantly lower DAOH-90 for all percentiles. The multivariable quantile regression confirmed that notably complications and poor performance status had great impact on DAOH-90.</p> Conclusion <p>DAOH-90 was associated with several demographic and comorbidity related variables, including severe surgical complications. DAOH-90 was also associated with long-term mortality.</p>

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Days alive and out of hospital at 90 days as a composite outcome measure in patients undergoing elective surgery for colorectal cancer– a nationwide, observational study

  • 期刊论文

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  • 发表日期：

    2025年12月17日

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  • Karoline Bendix Bräuner,
  • Maliha Mashkoor,
  • Rasmus Peuliche Vogelsang,
  • Rasmus Dahlin Bojesen,
  • Andreas Weinberger Rosen,
  • Ismail Gögenur

摘要

Objective

The aim of this study was to investigate the validity of DAOH-90 in a contemporary cohort of electively operated patients with colorectal cancer and explore its relationship with postoperative outcomes.

Design

The study was a retrospective, observational cohort study.

Settings

Data on patients operated from April 2014 to April 2019 were collected from the Danish Colorectal Cancer Group database and enriched by information from the Danish National Patient Register. DAOH-90 was analyzed by quantile regression for the 10th, 25th, 50th, 75th, and 90th percentile, using Mann-Whitney U-test, and association between DAOH-90 and 1-and 5-year mortality was analyzed using a Cox regression.

Patients

A total of 16,183 patients with colorectal cancer were included. Median DAOH-90 was 85 (IQR: 82–87). The 90-day mortality was 2.2%.

Main outcome measures

The primary outcome was the association between DAOH-90 quantiles and long-term mortality (1 and 5 years).

Results

There was significant association between DAOH-90 in the 25th, 50th and 75th quantile and death between 90 and 365 days (p = 0.0008-< 0.0001), and for death between 1 and 5 years (p = 0.0026-p < 0.0001). Both medical and surgical complications were associated with significantly lower DAOH-90 for all percentiles. The multivariable quantile regression confirmed that notably complications and poor performance status had great impact on DAOH-90.

Conclusion

DAOH-90 was associated with several demographic and comorbidity related variables, including severe surgical complications. DAOH-90 was also associated with long-term mortality.