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Purpose <p>The object of this study was to explore the risk factors for incomplete excision of colorectal polyps (CP) through a systematic review and meta-analysis.</p> Methods <p>A comprehensive research of various databases, including CNKI, Wanfang Data, VIP, PubMed, Embase, Cochrane Library, and Web of Science, was carried out to confirm case-control studies investigating the risk factors for incomplete excision of CP. The search deadline was March 20, 2023. Analyses of the data were performed utilizing Stata 15.0.</p> Results <p>The meta-analysis identified several factors significantly associated with the risk of residual or recurrent lesions. Polyps measuring ≥ 6&#xa0;mm [OR = 1.494; 95%CI: 1.117–1.999; <i>P</i> = 0.007], flat polyps [OR = 1.81; 95%CI: 1.35, 2.41; <i>P</i> &lt; 0.001], sessile serrated lesions [OR = 3.22; 95%CI: 1.93, 5.36; <i>P</i> &lt; 0.001], high-grade intraepithelial neoplasia [OR = 2.34; 95%CI: 1.15, 4.76; <i>P</i> = 0.019], and polyps that underwent piecewise excision [OR = 3.10; 95%CI: 1.96, 4.90; <i>P</i> &lt; 0.001] were all associated with increased risk. In contrast, adenomatous polyps [OR = 0.50; 95%CI: 0.26, 0.96; <i>P</i> = 0.036] were associated with a lower risk. Complete excision uncertainty was a protective factor for complete excision of CP [OR = 0.503, 95%CI (0.233, 1.087), <i>P</i> = 0.081]. In multivariate analysis, polyps ≥ 6&#xa0;mm remained an independent predictor of residual or recurrent lesions [OR = 1.494, 95%CI (1.117, 1.999), <i>P</i> = 0.007].</p> Conclusions <p>Based on existing evidence, CP ≥ 6&#xa0;mm, flat morphology, sessile serrated lesions, high-grade intraepithelial neoplasia, and piecewise excision could be risk factors for incomplete excision of CP.</p>

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Risk factors for incomplete excision of colorectal polyps: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月11日

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  • Zhongxin Sun,
  • Tengfei Cao,
  • Wen Wei,
  • Jiao Li,
  • Jing Shan,
  • Weidong Xi,
  • Xiaobin Sun

摘要

Purpose

The object of this study was to explore the risk factors for incomplete excision of colorectal polyps (CP) through a systematic review and meta-analysis.

Methods

A comprehensive research of various databases, including CNKI, Wanfang Data, VIP, PubMed, Embase, Cochrane Library, and Web of Science, was carried out to confirm case-control studies investigating the risk factors for incomplete excision of CP. The search deadline was March 20, 2023. Analyses of the data were performed utilizing Stata 15.0.

Results

The meta-analysis identified several factors significantly associated with the risk of residual or recurrent lesions. Polyps measuring ≥ 6 mm [OR = 1.494; 95%CI: 1.117–1.999; P = 0.007], flat polyps [OR = 1.81; 95%CI: 1.35, 2.41; P < 0.001], sessile serrated lesions [OR = 3.22; 95%CI: 1.93, 5.36; P < 0.001], high-grade intraepithelial neoplasia [OR = 2.34; 95%CI: 1.15, 4.76; P = 0.019], and polyps that underwent piecewise excision [OR = 3.10; 95%CI: 1.96, 4.90; P < 0.001] were all associated with increased risk. In contrast, adenomatous polyps [OR = 0.50; 95%CI: 0.26, 0.96; P = 0.036] were associated with a lower risk. Complete excision uncertainty was a protective factor for complete excision of CP [OR = 0.503, 95%CI (0.233, 1.087), P = 0.081]. In multivariate analysis, polyps ≥ 6 mm remained an independent predictor of residual or recurrent lesions [OR = 1.494, 95%CI (1.117, 1.999), P = 0.007].

Conclusions

Based on existing evidence, CP ≥ 6 mm, flat morphology, sessile serrated lesions, high-grade intraepithelial neoplasia, and piecewise excision could be risk factors for incomplete excision of CP.