Scholarlink

Background <p>To analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).</p> Methods <p>GC patients were retrospectively enrolled (<i>n</i> = 405), with their baseline data, 2-year follow-up records, and prognosis collected and analyzed. miR-155 and miR-543 expression levels in GC tissues were first predicted online and then determined in GC patient tissues using RT-qPCR. The correlations between miR-155 and miR-543 expression patterns and the U value of HP infection were analyzed through Spearman coefficient. A multivariate Cox regression model was established to analyze the risk factors for 2-year postoperative death of HP-positive GC patients. Kaplan-Meier curves were plotted to analyze the impact of miR-155 and miR-543 on the 2-year prognosis of HP-positive GC patients.</p> Results <p>miR-155 and miR-543 were upregulated in GC tissues and cells, with significantly higher expression levels in HP-positive compared to HP-negative patients. miR-155 and miR-543 expression changes were correlated with the HP infection degree. There were significant differences in miR-155 and miR-543 expression patterns across tumor diameter, TNM staging, and lymph node metastasis degree. Upregulated miR-155 and miR-543, TNM stage III, and lymph node metastasis were independent risk factors for 2-year postoperative death in HP-positive GC patients. Upregulated miR-155 and miR-543 increased the 2-year postoperative death rate.</p> Conclusion <p>miR-155 and miR-543 were upregulated in HP-positive GC patients, and their expression changes were correlated with HP infection degree. High miR-155 and miR-543 expression increased the risk of 2-year postoperative death in HP-positive GC patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月29日

查看全文
  • Ziwei Wang,
  • Xinxin Zhou,
  • Mosang Yu,
  • Xin Hu

摘要

Background

To analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).

Methods

GC patients were retrospectively enrolled (n = 405), with their baseline data, 2-year follow-up records, and prognosis collected and analyzed. miR-155 and miR-543 expression levels in GC tissues were first predicted online and then determined in GC patient tissues using RT-qPCR. The correlations between miR-155 and miR-543 expression patterns and the U value of HP infection were analyzed through Spearman coefficient. A multivariate Cox regression model was established to analyze the risk factors for 2-year postoperative death of HP-positive GC patients. Kaplan-Meier curves were plotted to analyze the impact of miR-155 and miR-543 on the 2-year prognosis of HP-positive GC patients.

Results

miR-155 and miR-543 were upregulated in GC tissues and cells, with significantly higher expression levels in HP-positive compared to HP-negative patients. miR-155 and miR-543 expression changes were correlated with the HP infection degree. There were significant differences in miR-155 and miR-543 expression patterns across tumor diameter, TNM staging, and lymph node metastasis degree. Upregulated miR-155 and miR-543, TNM stage III, and lymph node metastasis were independent risk factors for 2-year postoperative death in HP-positive GC patients. Upregulated miR-155 and miR-543 increased the 2-year postoperative death rate.

Conclusion

miR-155 and miR-543 were upregulated in HP-positive GC patients, and their expression changes were correlated with HP infection degree. High miR-155 and miR-543 expression increased the risk of 2-year postoperative death in HP-positive GC patients.