Scholarlink

Objective <p>There is limited research on the association between serum albumin to creatinine ratio (sACR) and non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the association between sACR and NAFLD risk in non-obese Chinese individuals.</p> Methods <p>This longitudinal cohort study comprised 14,698 non-obese individuals with normal LDL-c levels followed from January 2010 to December 2014. We analyzed the relationship between sACR and NAFLD risk employing Cox proportional hazards regression models. Cox proportional hazards regression with cubic spline functions was applied to examine the non-linear relationship between sACR and NAFLD. We conducted various sensitivity and subgroup analyses to validate our findings.</p> Results <p>Throughout the follow-up (median 35.4 months), 13.80% of the cohort (<i>n</i> = 2,029) progressed to NAFLD. After multivariable adjustment, each unit increment in sACR corresponded to a 3.3% reduction in NAFLD incidence (HR = 0.967, 95% CI: 0.963–0.972, <i>P</i> &lt; 0.001). A non-linear relationship was evident, featuring a critical value at sACR = 44.675, beyond which the protective effect strengthened (HR = 0.961, 95% CI: 0.955–0.967) compared to levels below this cutoff (HR = 0.979, 95% CI: 0.967–0.991). Sensitivity analyses validated the robustness of our findings. Subgroup analysis demonstrated a stronger relationship in individuals with HDL-c &lt; 1.0 mmol/L (HR = 0.942, 95% CI: 0.932–0.969) than in those with HDL-c ≥ 1.0 mmol/L (HR = 0.969, 95% CI: 0.964–0.974, P for interaction = 0.001).</p> Conclusion <p>This study demonstrates an inverse and non-linear relationship between sACR and NAFLD risk in non-obese Chinese individuals with normal LDL-c levels. The protective association is stronger when sACR exceeds 44.675. From a preventive and therapeutic perspective, maintaining sACR above this threshold may help reduce NAFLD risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between serum albumin to creatinine ratio and non-alcoholic fatty liver disease: a longitudinal cohort study in non-obese Chinese individuals

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月27日

查看全文
  • Weitao Wu,
  • Donghai Wu,
  • Fanglan Chen,
  • Shihua Ding,
  • Ying Ying,
  • Dayong Sun,
  • Haofei Hu

摘要

Objective

There is limited research on the association between serum albumin to creatinine ratio (sACR) and non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the association between sACR and NAFLD risk in non-obese Chinese individuals.

Methods

This longitudinal cohort study comprised 14,698 non-obese individuals with normal LDL-c levels followed from January 2010 to December 2014. We analyzed the relationship between sACR and NAFLD risk employing Cox proportional hazards regression models. Cox proportional hazards regression with cubic spline functions was applied to examine the non-linear relationship between sACR and NAFLD. We conducted various sensitivity and subgroup analyses to validate our findings.

Results

Throughout the follow-up (median 35.4 months), 13.80% of the cohort (n = 2,029) progressed to NAFLD. After multivariable adjustment, each unit increment in sACR corresponded to a 3.3% reduction in NAFLD incidence (HR = 0.967, 95% CI: 0.963–0.972, P < 0.001). A non-linear relationship was evident, featuring a critical value at sACR = 44.675, beyond which the protective effect strengthened (HR = 0.961, 95% CI: 0.955–0.967) compared to levels below this cutoff (HR = 0.979, 95% CI: 0.967–0.991). Sensitivity analyses validated the robustness of our findings. Subgroup analysis demonstrated a stronger relationship in individuals with HDL-c < 1.0 mmol/L (HR = 0.942, 95% CI: 0.932–0.969) than in those with HDL-c ≥ 1.0 mmol/L (HR = 0.969, 95% CI: 0.964–0.974, P for interaction = 0.001).

Conclusion

This study demonstrates an inverse and non-linear relationship between sACR and NAFLD risk in non-obese Chinese individuals with normal LDL-c levels. The protective association is stronger when sACR exceeds 44.675. From a preventive and therapeutic perspective, maintaining sACR above this threshold may help reduce NAFLD risk.