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Background <p>The C-Reactive protein-triglyceride-glucose index (CTI), a novel composite biomarker integrating inflammation and insulin resistance, has shown promise in predicting metabolic and inflammatory outcomes. However, its association with bowel dysfunction remains unexplored.</p> Methods <p>This population-based cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010 cycles. A total of 4,165 participants were included after rigorous exclusion criteria. CTI was calculated using the formula: 0.412 × Ln(CRP) + TyG, where TyG represents the triglyceride-glucose index. Diarrhea and constipation were defined based on the Bristol Stool Form Scale and bowel frequency. Logistic regressions were employed to assess associations between CTI and bowel dysfunction. Subgroup and mediation analyses were conducted to explore potential effect modifications and underlying mechanisms.</p> Results <p>Higher CTI levels were significantly associated with increased diarrhea risk (adjusted OR = 1.58, 95% CI: 1.20–2.10, <i>P</i> &lt; 0.05), with a dose–response relationship observed across CTI quartiles (<i>P</i> for trend = 0.047). No significant association was found between CTI and constipation (<i>P</i> &gt; 0.05). Subgroup analyses revealed consistent associations across most demographic and clinical characteristics, with no significant interaction effects (all<i> P</i> for interaction &gt; 0.05). Mediation analysis revealed that body mass index (BMI), waistline and hypertension significantly mediated the association between CTI and diarrhea.</p> Conclusion <p>CTI is associated with the occurrence of diarrhea and may serve as a useful biomarker for identifying individuals at higher risk of diarrhea.</p>

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CTI as a biomarker for diarrhea in U.S. adults: insights from NHANES 2005–2010

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  • 发表日期：

    2025年8月6日

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  • Yucheng Yang,
  • Wanju Jiang,
  • Peng Liao,
  • Tao Du

摘要

Background

The C-Reactive protein-triglyceride-glucose index (CTI), a novel composite biomarker integrating inflammation and insulin resistance, has shown promise in predicting metabolic and inflammatory outcomes. However, its association with bowel dysfunction remains unexplored.

Methods

This population-based cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010 cycles. A total of 4,165 participants were included after rigorous exclusion criteria. CTI was calculated using the formula: 0.412 × Ln(CRP) + TyG, where TyG represents the triglyceride-glucose index. Diarrhea and constipation were defined based on the Bristol Stool Form Scale and bowel frequency. Logistic regressions were employed to assess associations between CTI and bowel dysfunction. Subgroup and mediation analyses were conducted to explore potential effect modifications and underlying mechanisms.

Results

Higher CTI levels were significantly associated with increased diarrhea risk (adjusted OR = 1.58, 95% CI: 1.20–2.10, P < 0.05), with a dose–response relationship observed across CTI quartiles (P for trend = 0.047). No significant association was found between CTI and constipation (P > 0.05). Subgroup analyses revealed consistent associations across most demographic and clinical characteristics, with no significant interaction effects (all P for interaction > 0.05). Mediation analysis revealed that body mass index (BMI), waistline and hypertension significantly mediated the association between CTI and diarrhea.

Conclusion

CTI is associated with the occurrence of diarrhea and may serve as a useful biomarker for identifying individuals at higher risk of diarrhea.