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Objective <p>To investigate the relationships between red cell distribution width (RDW), other inflammation-related markers and clinical features with the clinical and radiological severity of diverticulitis.</p> Methods <p>This retrospective cohort study included 250 patients diagnosed with acute diverticulitis. Radiological diverticulitis severity was determined by the Hinchey classification. Clinical diverticulitis severity was determined based on the treatment applied (invasive versus conservative/medical treatment).</p> Results <p>High platelet count (<i>p</i> = 0.001) and high CRP (<i>p</i> &lt; 0.001) were independently associated with the Hinchey Class II-IV. Need for invasive treatment was independently associated with presence of Hinchey stage II-IV (<i>p</i> &lt; 0.001) and high (&gt; 13.75) RDW (<i>p</i> &lt; 0.001). With a cut-off value of &gt; 13.75, RDW was able to predict patients requiring invasive treatment [Sensitivity = 75.86%, Specificity = 63.87%, AUC (95% CI) = 0.657 (0.580–0.734), <i>p</i> &lt; 0.001].</p> Conclusiosn <p>RDW, which is an inexpensive and readily-available parameter, may be a supportive measure in the prediction of the clinical severity of diverticulitis. Together with other clinical and laboratory data, RDW could help identify patients with worse prognosis, facilitating appropriate decisions and precautions in their management.</p>

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Red cell distribution width as a potential new biomarker to predict the clinical severity of acute diverticulitis

  • 期刊论文

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  • 发表日期：

    2025年5月13日

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  • Melek Yalcin Koc,
  • Mehmet Aykut Yildirim,
  • Suleyman Sakir Tavli,
  • Abdullah Gurhan Duyan

摘要

Objective

To investigate the relationships between red cell distribution width (RDW), other inflammation-related markers and clinical features with the clinical and radiological severity of diverticulitis.

Methods

This retrospective cohort study included 250 patients diagnosed with acute diverticulitis. Radiological diverticulitis severity was determined by the Hinchey classification. Clinical diverticulitis severity was determined based on the treatment applied (invasive versus conservative/medical treatment).

Results

High platelet count (p = 0.001) and high CRP (p < 0.001) were independently associated with the Hinchey Class II-IV. Need for invasive treatment was independently associated with presence of Hinchey stage II-IV (p < 0.001) and high (> 13.75) RDW (p < 0.001). With a cut-off value of > 13.75, RDW was able to predict patients requiring invasive treatment [Sensitivity = 75.86%, Specificity = 63.87%, AUC (95% CI) = 0.657 (0.580–0.734), p < 0.001].

Conclusiosn

RDW, which is an inexpensive and readily-available parameter, may be a supportive measure in the prediction of the clinical severity of diverticulitis. Together with other clinical and laboratory data, RDW could help identify patients with worse prognosis, facilitating appropriate decisions and precautions in their management.