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Background <p>Magnetic resonance imaging (MRI) may be a non-invasive tool for managing warm hepatic ischemia-reperfusion injury (WHIRI).</p> Purpose <p>We aimed to evaluate the diagnostic utility of the R2* values derived from 3.0T blood oxygen level-dependent (BOLD) MRI in assessing the severity of WHIRI.</p> Methods <p>Fifty healthy adult New Zealand white rabbits were randomly divided into 5 groups with 10 rabbits in each. The experimental groups (40 rabbits) underwent clamping of the hepatic artery and the portal vein for 10, 20, 30, or 40&#xa0;min, followed by 6&#xa0;h of reperfusion to induce WHIRI. The other 10 rabbits comprised the normal control group. All animals were underwent conventional 3.0 T and BOLD MRI. Animals were euthanized and the serum levels of biochemical indicators were determined. Correlations between R2* values, biochemical indicators, and WHIRI staging were assessed using Spearman’s rank correlation coefficient. The diagnostic efficacy of R2* values was evaluated using ROC curves.</p> Results <p>R2* values increased gradually with prolonged warm ischemia with significant differences across groups (F = 133.25, <i>P</i> &lt; 0.05). A strong positive correlation was detected between R2* values and WHIRI staging (<i>r</i> = 0.878, <i>P</i> = 0.000). Biochemical indicators (ALT, AST, LDH, MDA, and MPO) increased significantly, while SOD levels decreased with prolonged warm ischemia (<i>P</i> &lt; 0.05). R2* values exhibited a strong positive correlation with biochemical indicators (<i>r</i> &gt; 0.495) and a negative correlation with SOD levels (<i>r</i>=-0.658). The diagnostic efficacy of the R2* values was highest for predicting WHIRI above stage S4 (AUC = 1.000).</p> Conclusion <p>R2* values on BOLD MRI provide a sensitive and accurate method for assessing WHIRI. The diagnostic efficacy of the R2* values was the best for predicting WHIRI above stage S4.</p>

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Evaluating the diagnostic significance of the R2* value on 3.0T MRI for assessing the severity of warm hepatic ischemia-reperfusion injury

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  • 发表日期：

    2025年5月12日

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  • Shichao Xu,
  • Qian Ji,
  • Jing Xu

摘要

Background

Magnetic resonance imaging (MRI) may be a non-invasive tool for managing warm hepatic ischemia-reperfusion injury (WHIRI).

Purpose

We aimed to evaluate the diagnostic utility of the R2* values derived from 3.0T blood oxygen level-dependent (BOLD) MRI in assessing the severity of WHIRI.

Methods

Fifty healthy adult New Zealand white rabbits were randomly divided into 5 groups with 10 rabbits in each. The experimental groups (40 rabbits) underwent clamping of the hepatic artery and the portal vein for 10, 20, 30, or 40 min, followed by 6 h of reperfusion to induce WHIRI. The other 10 rabbits comprised the normal control group. All animals were underwent conventional 3.0 T and BOLD MRI. Animals were euthanized and the serum levels of biochemical indicators were determined. Correlations between R2* values, biochemical indicators, and WHIRI staging were assessed using Spearman’s rank correlation coefficient. The diagnostic efficacy of R2* values was evaluated using ROC curves.

Results

R2* values increased gradually with prolonged warm ischemia with significant differences across groups (F = 133.25, P < 0.05). A strong positive correlation was detected between R2* values and WHIRI staging (r = 0.878, P = 0.000). Biochemical indicators (ALT, AST, LDH, MDA, and MPO) increased significantly, while SOD levels decreased with prolonged warm ischemia (P < 0.05). R2* values exhibited a strong positive correlation with biochemical indicators (r > 0.495) and a negative correlation with SOD levels (r=-0.658). The diagnostic efficacy of the R2* values was highest for predicting WHIRI above stage S4 (AUC = 1.000).

Conclusion

R2* values on BOLD MRI provide a sensitive and accurate method for assessing WHIRI. The diagnostic efficacy of the R2* values was the best for predicting WHIRI above stage S4.