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Background <p>To examine the progression-free survival from disease worsening after the implementation of routine screening for psychological problems in hospitalized patients with inflammatory bowel diseases (IBDs) during a long-term follow-up.</p> Methods <p>The retrospective cohort study enrolled 1265 patients with active IBDs. Their records were stratified into screening cohort (<i>n</i> = 827), receiving screening for psychological problems within 48&#xa0;h after admission, and a 2:1 propensity score matching was utilized to match cases without screening as controls (<i>n</i> = 438). Primary endpoint was the progression-free survival from disease worsening defined as any IBDs-related emergency room visit, hospitalization or surgery during 12 months post-discharge. Secondary outcomes included quality of life (QoL) using quality-adjusted life years (QALYs) and adverse events.</p> Results <p>The rate of progression-free survival from IBDs worsening was observed in 73.2% of patients in screening cohort, while 53.4% of cases in control cohort (odds ratio (OR) = 2.376 (95%CI: 1.864, 3.028), <i>p</i> &lt; 0.001). Compared with controls, cases in screening cohort showed a superior mean of progression-free survival (log-rank <i>p</i> &lt; 0.001) and a greater QALYs during the 12-month follow-up (<i>p</i> &lt; 0.001). Patients in screening cohort were more likely to have hospital-acquired venous thromboembolism and pneumonia due to a longer hospital stay. No severe adverse events were observed.</p> Conclusions <p>There was evidence that patients in screening cohort had a better progression-free survival from IBDs worsening than those without these conditions, and also exhibited a better QoL during 12-month follow-up. It should be encouraged that hospitalized IBDs in active phase should be routinely screened for psychological problems that could influence disease course.</p>

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Routine psychological problems screening in hospitalized inflammatory bowel diseases and its effect for progression-free survival from disease worsening

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Wen Cao,
  • Shu Chen,
  • Qi Sun,
  • Xiaoli Zhou

摘要

Background

To examine the progression-free survival from disease worsening after the implementation of routine screening for psychological problems in hospitalized patients with inflammatory bowel diseases (IBDs) during a long-term follow-up.

Methods

The retrospective cohort study enrolled 1265 patients with active IBDs. Their records were stratified into screening cohort (n = 827), receiving screening for psychological problems within 48 h after admission, and a 2:1 propensity score matching was utilized to match cases without screening as controls (n = 438). Primary endpoint was the progression-free survival from disease worsening defined as any IBDs-related emergency room visit, hospitalization or surgery during 12 months post-discharge. Secondary outcomes included quality of life (QoL) using quality-adjusted life years (QALYs) and adverse events.

Results

The rate of progression-free survival from IBDs worsening was observed in 73.2% of patients in screening cohort, while 53.4% of cases in control cohort (odds ratio (OR) = 2.376 (95%CI: 1.864, 3.028), p < 0.001). Compared with controls, cases in screening cohort showed a superior mean of progression-free survival (log-rank p < 0.001) and a greater QALYs during the 12-month follow-up (p < 0.001). Patients in screening cohort were more likely to have hospital-acquired venous thromboembolism and pneumonia due to a longer hospital stay. No severe adverse events were observed.

Conclusions

There was evidence that patients in screening cohort had a better progression-free survival from IBDs worsening than those without these conditions, and also exhibited a better QoL during 12-month follow-up. It should be encouraged that hospitalized IBDs in active phase should be routinely screened for psychological problems that could influence disease course.