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Background <p>Current evidence on the associations between insulin resistance (IR) and <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection remains limited. This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR), and <i>H. pylori</i> infection in U.S. populations.</p> Methods <p>This cross-sectional study involving 939 U.S. participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. The associations between three IR surrogate markers and <i>H. pylori</i> infection were respectively investigated using logistic regression model, restricted cubic spline (RCS) curve and subgroup analysis.</p> Results <p>Three IR surrogate markers levels were significantly elevated in <i>H. pylori</i> infection participants. There was a positive association between three IR surrogate markers and <i>H. pylori</i> infection, even after adjusting for potential confounding variables by three different models. In subgroup analysis, the adjusted association between three IR surrogate markers and <i>H. pylori</i> infection were more likely to be observed in female and Non-Hispanic White. Additionally, the RCS curve revealed a positive linear correlation between TyG index and <i>H. pylori</i> infection across all three models, and between METS-IR and <i>H. pylori</i> infection in Model 3. However, a positive nonlinear correlation was observed between TG/HDL-C ratio and <i>H. pylori</i> infection in all three models.</p> Conclusions <p>These findings suggest that non-insulin-based IR surrogate markers including TyG index, TG/HDL-C ratio, and METS-IR were all positively associated with <i>H. pylori</i> infection. These markers may serve as the potential indicators for identifying the risk of <i>H. pylori</i> infection in U.S. populations.</p> Clinical trial number <p>Not applicable.</p>

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Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月21日

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  • Jiayu Qiu,
  • Yueming Yu,
  • Dingwei Liu,
  • Sihai Chen,
  • Youhua Wang,
  • Jianxiang Peng,
  • Jinliang Xie,
  • Chengyun Wu,
  • Feng Zhou,
  • Hui Fang,
  • Qirui Lai,
  • Yong Xie

摘要

Background

Current evidence on the associations between insulin resistance (IR) and Helicobacter pylori (H. pylori) infection remains limited. This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR), and H. pylori infection in U.S. populations.

Methods

This cross-sectional study involving 939 U.S. participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. The associations between three IR surrogate markers and H. pylori infection were respectively investigated using logistic regression model, restricted cubic spline (RCS) curve and subgroup analysis.

Results

Three IR surrogate markers levels were significantly elevated in H. pylori infection participants. There was a positive association between three IR surrogate markers and H. pylori infection, even after adjusting for potential confounding variables by three different models. In subgroup analysis, the adjusted association between three IR surrogate markers and H. pylori infection were more likely to be observed in female and Non-Hispanic White. Additionally, the RCS curve revealed a positive linear correlation between TyG index and H. pylori infection across all three models, and between METS-IR and H. pylori infection in Model 3. However, a positive nonlinear correlation was observed between TG/HDL-C ratio and H. pylori infection in all three models.

Conclusions

These findings suggest that non-insulin-based IR surrogate markers including TyG index, TG/HDL-C ratio, and METS-IR were all positively associated with H. pylori infection. These markers may serve as the potential indicators for identifying the risk of H. pylori infection in U.S. populations.

Clinical trial number

Not applicable.