Background <p>Obesity has become a public health concern as its prevalence has increased rapidly around the world, including Malaysia. Primary care physicians (PCPs) are the first point of contact for obese patients, playing a crucial role in managing obesity. This study aims to determine the level of obesity care knowledge and practices among PCPs and to identify factors associated with them.</p> Methods <p>A cross-sectional study was conducted using a self-administered questionnaire distributed physically and online to PCPs. Pearson Chi-Square test was used to identify associations between demographic characteristics and obesity-related knowledge while the relationship between knowledge and practice scores was explored using regression analysis.</p> Results <p>A total of 126 PCPs participated in the study. Of these, 72% demonstrated a good level of knowledge, and 66% showed good practices in obesity care. Use of clinical practice guidelines (CPGs) was significantly associated with higher knowledge scores, while both CPG use and prior training were significantly associated with better practice scores (<i>p</i> &lt; 0.05). A moderate positive correlation was observed between knowledge and practice scores (<i>r</i> = 0.397, <i>p</i> &lt; 0.001).</p> Conclusion <p>PCPs have good obesity care knowledge and practice. Those using CPGs and with training were better prepared, resulting in improved practices. Enhancing awareness of these factors is crucial for future knowledge and practice improvements.</p>