<p>Meta-analysis is a widely used method for synthesizing results from multiple studies across diverse fields. A central challenge in meta-analysis is assessing between-study inconsistency, which can arise from differences in study populations, methodological heterogeneity, or the presence of outliers. Conventional tools such as the <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(Q\)</EquationSource> </InlineEquation> and <InlineEquation ID="IEq2"> <EquationSource Format="TEX">\({I}^{2}\)</EquationSource> </InlineEquation>&#xa0;statistics could be limited in power, especially when the number of studies is small or when the between-study distribution deviates from normality. To address these limitations, we propose a family of alternative <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(Q\)</EquationSource> </InlineEquation>-like statistics and a hybrid test that adaptively combines their strengths. We also introduce new measures to quantify inconsistency based on these statistics. Simulation studies demonstrate that the hybrid test performs robustly across a wide range of inconsistency patterns, including heavy-tailed, skewed, and contaminated distributions. We further illustrate the practical utility of our methods using three real-world meta-analyses. These approaches offer more flexible and powerful tools for detecting and quantifying inconsistency in meta-analytic practice.</p>

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Alternative tests and measures for between-study inconsistency in meta-analysis

  • Zhiyuan Yu,
  • Mengli Xiao,
  • Xing Xing,
  • Lifeng Lin

摘要

Meta-analysis is a widely used method for synthesizing results from multiple studies across diverse fields. A central challenge in meta-analysis is assessing between-study inconsistency, which can arise from differences in study populations, methodological heterogeneity, or the presence of outliers. Conventional tools such as the \(Q\) and \({I}^{2}\)  statistics could be limited in power, especially when the number of studies is small or when the between-study distribution deviates from normality. To address these limitations, we propose a family of alternative \(Q\) -like statistics and a hybrid test that adaptively combines their strengths. We also introduce new measures to quantify inconsistency based on these statistics. Simulation studies demonstrate that the hybrid test performs robustly across a wide range of inconsistency patterns, including heavy-tailed, skewed, and contaminated distributions. We further illustrate the practical utility of our methods using three real-world meta-analyses. These approaches offer more flexible and powerful tools for detecting and quantifying inconsistency in meta-analytic practice.