Background <p>The mortality risk of patients presenting with ST-elevation myocardial infarction (STEMI) has been extensively researched. Even though STEMI can be diagnosed before hospital admission, prehospital mortality has been less frequently studied. We aimed to analyze the outcomes of patients with STEMI requiring out-of-hospital cardiopulmonary resuscitation (CPR).</p> Methods <p>From a large, nationwide prehospital case report database, we collected data from 668 patients requiring CPR because of ambulance-witnessed OHCA (out-of-hospital cardiac arrest) who were diagnosed with STEMI by ECG before cardiac arrest. Utstein-style consensus reporting guidelines were followed. The endpoint was hospital admission with spontaneous circulation. In addition to descriptive statistics, we also aimed to identify predictors of the outcome using multivariable logistic regression. Model performance was characterized by c-statistics and multiple fitting methods. Internal validation was performed using calibration intercept and slope.</p> Results <p>Using CPR initial rhythm, age, initial heart rate, initial systolic blood pressure, and ECG localization of STEMI as predictors, we found that the constructed logistic regression model showed good discriminative ability, with a c-statistic of 0.844 (95% CI = 0.8105–0.8787). The overall model fit was good, with Hosmer &amp; Lemeshow <i>p</i> = 0.979. The value of Nagelkerke R² test of 0.445 indicated a strong relationship between predictors and outcome. The Z-value of calibration slope was relative to slope = 1 (95% CI = 0.85–1.16).</p> Conclusions <p>This model can be used to estimate the probability of hospital admission following resuscitation due to ambulance-witnessed OHCA in patients with STEMI. Further studies are needed to improve the possibility of definitive in-hospital treatment for a better survival rate.</p> Clinical trial number <p>Not applicable.</p>