Scholarlink

Background <p>Essential hypertension is influenced by conventional risk factors and genetic susceptibility. We tested the prespecified hypothesis that the combined AGT M235T-ACE I/D TT/DD genotype is associated with essential hypertension in Vietnamese adults.</p> Methods <p>We conducted a hospital-based case-control study among 471 Vietnamese Kinh adults at the University Medical Center, Ho Chi Minh City, Vietnam, including 238 cardiology-clinic participants with essential hypertension and 233 health-screening participants without hypertension. Hypertension was defined according to Vietnamese guideline thresholds as office systolic blood pressure  ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or current antihypertensive treatment; controls had no history of hypertension, were not receiving antihypertensive medication, and had office blood pressure &lt; 140/90 mmHg. The primary exposure was TT/DD versus non-TT/DD. Multivariable logistic regression adjusted for age, sex, overweight or obesity, diabetes mellitus, salt-rich diet, smoking, alcohol misuse, physical inactivity, and family history of hypertension.</p> Results <p>TT/DD was observed in 37 of 238 cases (15.55%) and 15 of 233 controls (6.44%). TT/DD was associated with hypertension in crude analysis (OR 2.67, 95% CI 1.38–5.40; <i>p</i> = 0.002) and remained associated after adjustment (adjusted OR 3.26, 95% CI 1.53–6.92; <i>p</i> = 0.002). In an exploratory six-category model using (MM + MT)/II as the reference, TT/DD was the only genotype category significantly associated with hypertension, although the estimate was imprecise (adjusted OR 3.46, 95% CI 1.24–9.70; <i>p</i> = 0.018).</p> Conclusions <p>The combined AGT M235T-ACE I/D TT/DD genotype was associated with essential hypertension in this hospital-based Vietnamese sample. Because of the case-control design, hospital-based recruitment, covariate imbalance, and absence of external replication, the finding should be interpreted as associative and hypothesis-generating.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Combined AGT M235T-ACE I/D genotype and risk of essential hypertension in Vietnamese adults: a hospital-based case-control study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月17日

查看全文
  • Thanh Tuan Tran,
  • Ngoc Hoa Chau,
  • Duc Khanh Nguyen

摘要

Background

Essential hypertension is influenced by conventional risk factors and genetic susceptibility. We tested the prespecified hypothesis that the combined AGT M235T-ACE I/D TT/DD genotype is associated with essential hypertension in Vietnamese adults.

Methods

We conducted a hospital-based case-control study among 471 Vietnamese Kinh adults at the University Medical Center, Ho Chi Minh City, Vietnam, including 238 cardiology-clinic participants with essential hypertension and 233 health-screening participants without hypertension. Hypertension was defined according to Vietnamese guideline thresholds as office systolic blood pressure  ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or current antihypertensive treatment; controls had no history of hypertension, were not receiving antihypertensive medication, and had office blood pressure < 140/90 mmHg. The primary exposure was TT/DD versus non-TT/DD. Multivariable logistic regression adjusted for age, sex, overweight or obesity, diabetes mellitus, salt-rich diet, smoking, alcohol misuse, physical inactivity, and family history of hypertension.

Results

TT/DD was observed in 37 of 238 cases (15.55%) and 15 of 233 controls (6.44%). TT/DD was associated with hypertension in crude analysis (OR 2.67, 95% CI 1.38–5.40; p = 0.002) and remained associated after adjustment (adjusted OR 3.26, 95% CI 1.53–6.92; p = 0.002). In an exploratory six-category model using (MM + MT)/II as the reference, TT/DD was the only genotype category significantly associated with hypertension, although the estimate was imprecise (adjusted OR 3.46, 95% CI 1.24–9.70; p = 0.018).

Conclusions

The combined AGT M235T-ACE I/D TT/DD genotype was associated with essential hypertension in this hospital-based Vietnamese sample. Because of the case-control design, hospital-based recruitment, covariate imbalance, and absence of external replication, the finding should be interpreted as associative and hypothesis-generating.