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Background <p>Daidzein, an isoflavone in soy, is metabolized to <i>O</i>-desmethylangolensin (ODMA) by select gut bacteria. Not all individuals have gut microbiomes capable of producing ODMA, resulting in ODMA producer and non-producer metabotypes. A limited body of research suggests that ODMA producers have lower systolic blood pressure, percent body fat and total cholesterol, compared to non-producers. More work is needed to confirm this relationship in other populations.</p> Methods <p>Data from the Study of Women’s Health Across the Nation (SWAN), a study of women in their middle years, was used. A subset of women who reported consumption of isoflavones in diet or supplements was included for this analysis. Urinary ODMA and daidzein of 148 participants were measured via HPLC-MS-MS to classify metabotypes: ODMA (nmol/L)/daidzein (nmol/L) = 0, non-producers (<i>n</i> = 23); ODMA (nmol/L)/daidzein (nmol/L) &gt; 0 but less than 0.5, low-producers (<i>n</i> = 90); and ODMA (nmol/L)/daidzein (nmol/L) &gt; 0.5, high-producers (<i>n</i> = 35). Multivariable linear regression models were used to compare cardiovascular disease (CVD) risk markers among groups. Models were adjusted for age, race, self-reported health, blood pressure medication, smoking, menopausal status and anthropometry.</p> Results <p>ODMA non-producers had higher systolic blood pressure (adj. mean difference = 7.6 mmHg, 95% CI: 1.1, 14.1, <i>p</i> = 0.02) compared to high producers. Another trend but not statistically significant difference observed included higher fasting serum glucose (adj. mean difference = 6.1&#xa0;mg/dl, CI: -0.9, 13.2, <i>p</i> = 0.09) in ODMA non-producers when compared to ODMA producers.</p> Conclusions <p>In this diverse sample of U.S. women, this study observed higher blood pressure in ODMA non-producers than ODMA producers. This aligns with prior work associating ODMA producers with a more favorable CVD risk profile compared to non-producers, and provides additional evidence that this gut microbial metabotype may be related to cardiovascular health.</p>

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Cardiovascular disease risk factors in women with O-desmethylangolensin producing and non-producing gut microbial metabotypes: an observational study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Holly Childs,
  • Cara L. Frankenfeld,
  • Allyson Dailey,
  • Robin Couch,
  • Margaret Slavin

摘要

Background

Daidzein, an isoflavone in soy, is metabolized to O-desmethylangolensin (ODMA) by select gut bacteria. Not all individuals have gut microbiomes capable of producing ODMA, resulting in ODMA producer and non-producer metabotypes. A limited body of research suggests that ODMA producers have lower systolic blood pressure, percent body fat and total cholesterol, compared to non-producers. More work is needed to confirm this relationship in other populations.

Methods

Data from the Study of Women’s Health Across the Nation (SWAN), a study of women in their middle years, was used. A subset of women who reported consumption of isoflavones in diet or supplements was included for this analysis. Urinary ODMA and daidzein of 148 participants were measured via HPLC-MS-MS to classify metabotypes: ODMA (nmol/L)/daidzein (nmol/L) = 0, non-producers (n = 23); ODMA (nmol/L)/daidzein (nmol/L) > 0 but less than 0.5, low-producers (n = 90); and ODMA (nmol/L)/daidzein (nmol/L) > 0.5, high-producers (n = 35). Multivariable linear regression models were used to compare cardiovascular disease (CVD) risk markers among groups. Models were adjusted for age, race, self-reported health, blood pressure medication, smoking, menopausal status and anthropometry.

Results

ODMA non-producers had higher systolic blood pressure (adj. mean difference = 7.6 mmHg, 95% CI: 1.1, 14.1, p = 0.02) compared to high producers. Another trend but not statistically significant difference observed included higher fasting serum glucose (adj. mean difference = 6.1 mg/dl, CI: -0.9, 13.2, p = 0.09) in ODMA non-producers when compared to ODMA producers.

Conclusions

In this diverse sample of U.S. women, this study observed higher blood pressure in ODMA non-producers than ODMA producers. This aligns with prior work associating ODMA producers with a more favorable CVD risk profile compared to non-producers, and provides additional evidence that this gut microbial metabotype may be related to cardiovascular health.