Scholarlink

Background <p>Reduced kidney function is a major contributor to cardiovascular morbidity and mortality worldwide, particularly among individuals with hypertension. The triglyceride–glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with renal dysfunction in multiple populations; however, data from Sub-Saharan Africa remain limited. We examined the association between the TyG index and reduced kidney function among hypertensive Nigerian adults.</p> Methods <p>In this cross-sectional study, 1,470 consecutively presenting hypertensive adults aged ≥ 18 years at a cardiac center in Lagos, Nigeria (2009–2024) were analyzed. Individuals with known diabetes, fasting glucose ≥ 126&#xa0;mg/dL, pregnancy, acute kidney injury, or incomplete data were excluded. Reduced kidney function was defined as estimated glomerular filtration rate (eGFR) &lt; 60 mL/min/1.73&#xa0;m² using the CKD-EPI 2021 race-free equation. The TyG index was analyzed as quartiles and as a standardized continuous variable. Multivariable logistic regression models were constructed. Sensitivity analyses included adjustment for HbA1c and exclusion of participants with HbA1c ≥ 6.5%. Restricted cubic spline and receiver operating characteristic analyses were performed. Estimated 10-year cardiovascular risk was calculated using the Framingham Risk Score.</p> Results <p>Reduced kidney function was present in 36.7% of participants. Compared with the lowest TyG index quartile, individuals in the highest quartile had higher odds of reduced kidney function (fully adjusted OR 3.14; 95% CI 2.25–4.39). Each 1-standard deviation increase in TyG index was associated with higher odds (adjusted OR 1.49; 95% CI 1.31–1.70). The association remained robust after adjustment for HbA1c and exclusion of participants with elevated HbA1c. Restricted cubic spline analysis demonstrated a log-linear relationship (p for non-linearity = 0.43). The TyG index showed modest discrimination (AUC 0.664).</p> Conclusions <p>Higher TyG index values are independently associated with reduced kidney function in hypertensive Nigerian adults, supporting a graded relationship between metabolic dysfunction and renal impairment. The TyG index may serve as a simple adjunct tool for cardio–renal risk stratification in resource-limited settings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Triglyceride-glucose index and reduced kidney function in hypertensive Nigerian adults: independent association within the cardio-renal continuum

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月1日

查看全文
  • Casmir Ezenwa Amadi,
  • Precious O. Akanbi,
  • Micah Okwah,
  • Amam C. Mbakwem,
  • Jayne N. Ajuluchukwu

摘要

Background

Reduced kidney function is a major contributor to cardiovascular morbidity and mortality worldwide, particularly among individuals with hypertension. The triglyceride–glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with renal dysfunction in multiple populations; however, data from Sub-Saharan Africa remain limited. We examined the association between the TyG index and reduced kidney function among hypertensive Nigerian adults.

Methods

In this cross-sectional study, 1,470 consecutively presenting hypertensive adults aged ≥ 18 years at a cardiac center in Lagos, Nigeria (2009–2024) were analyzed. Individuals with known diabetes, fasting glucose ≥ 126 mg/dL, pregnancy, acute kidney injury, or incomplete data were excluded. Reduced kidney function was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² using the CKD-EPI 2021 race-free equation. The TyG index was analyzed as quartiles and as a standardized continuous variable. Multivariable logistic regression models were constructed. Sensitivity analyses included adjustment for HbA1c and exclusion of participants with HbA1c ≥ 6.5%. Restricted cubic spline and receiver operating characteristic analyses were performed. Estimated 10-year cardiovascular risk was calculated using the Framingham Risk Score.

Results

Reduced kidney function was present in 36.7% of participants. Compared with the lowest TyG index quartile, individuals in the highest quartile had higher odds of reduced kidney function (fully adjusted OR 3.14; 95% CI 2.25–4.39). Each 1-standard deviation increase in TyG index was associated with higher odds (adjusted OR 1.49; 95% CI 1.31–1.70). The association remained robust after adjustment for HbA1c and exclusion of participants with elevated HbA1c. Restricted cubic spline analysis demonstrated a log-linear relationship (p for non-linearity = 0.43). The TyG index showed modest discrimination (AUC 0.664).

Conclusions

Higher TyG index values are independently associated with reduced kidney function in hypertensive Nigerian adults, supporting a graded relationship between metabolic dysfunction and renal impairment. The TyG index may serve as a simple adjunct tool for cardio–renal risk stratification in resource-limited settings.