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Background <p>Blood biomarkers can characterize the atrial substrate and help elucidate mechanisms of atrial fibrillation (AF) development. Understanding whether sedentary behavior affects AF-related biomarkers may inform prevention strategies.</p> Methods <p>We studied 252 participants in PREDIMED-Plus, a multicenter randomized trial in Spain for the primary prevention of cardiovascular disease. Participants wore wrist accelerometers for one week at baseline and at least once during follow-up (years 3 or 5). Blood samples were collected at each time point to measure selected biomarkers: propeptide of procollagen type I, high-sensitivity (hs) troponin T (hsTnT), hs C-reactive protein, 3-nitrotyrosine, and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP). Using isotemporal substitution, we estimated the effect of replacing 30&#xa0;min/day of sedentary time (&lt; 1.5 METs in waking time) with low-intensity physical activity (LPA, 1.5–3 METs), moderate-to-vigorous PA (MVPA, &gt; 3 METs), or time in bed (bedtime to wake-up) on log-transformed biomarker levels, cross-sectionally and longitudinally, via linear regression and mixed models.</p> Results <p>At baseline, participants (mean age 65 ± 4.9 years, BMI 32.2 ± 3.3&#xa0;kg/m², 40% women) showed no significant cross-sectional associations between substituting sedentary time and biomarker levels. After 5 years, replacing baseline 30-min of sedentary time per day with LPA or MVPA was associated with lower hs-TnT concentrations compared to baseline (-4%, 95% CI -8%, -1%; and − 2%, 95% CI -7%, 4%). Substitutions showed nonsignificant reductions in NT-proBNP but no consistent associations with other biomarkers.</p> Conclusions <p>Among overweight/obese individuals, replacing sedentary time with PA was associated with favorable 5-year changes of hs-TnT, but not other AF-related biomarkers.</p> Trial registration <p>The trial was registered on July 24, 2014, at ISRCTN (ISRCTN89898870) [<a href="http://www.isrctn.com/ISRCTN89898870">www.isrctn.com/ISRCTN89898870</a> (accessed on December 10, 2025)].</p>

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Sedentary behavior with atrial fibrillation-related biomarkers in overweight or obese adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月13日

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  • Linzi Li,
  • Amit Shah,
  • Yi-An Ko,
  • Dayna A. Johnson,
  • Dora Romaguera,
  • Angel M. Alonso-Gómez,
  • Estefanía Toledo,
  • Cristina Razquin,
  • Jadwiga Konieczna,
  • Miguel Angel Martinez-Gonzalez,
  • Julia Warnberg,
  • Montserrat Fitó,
  • Alvaro Alonso

摘要

Background

Blood biomarkers can characterize the atrial substrate and help elucidate mechanisms of atrial fibrillation (AF) development. Understanding whether sedentary behavior affects AF-related biomarkers may inform prevention strategies.

Methods

We studied 252 participants in PREDIMED-Plus, a multicenter randomized trial in Spain for the primary prevention of cardiovascular disease. Participants wore wrist accelerometers for one week at baseline and at least once during follow-up (years 3 or 5). Blood samples were collected at each time point to measure selected biomarkers: propeptide of procollagen type I, high-sensitivity (hs) troponin T (hsTnT), hs C-reactive protein, 3-nitrotyrosine, and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP). Using isotemporal substitution, we estimated the effect of replacing 30 min/day of sedentary time (< 1.5 METs in waking time) with low-intensity physical activity (LPA, 1.5–3 METs), moderate-to-vigorous PA (MVPA, > 3 METs), or time in bed (bedtime to wake-up) on log-transformed biomarker levels, cross-sectionally and longitudinally, via linear regression and mixed models.

Results

At baseline, participants (mean age 65 ± 4.9 years, BMI 32.2 ± 3.3 kg/m², 40% women) showed no significant cross-sectional associations between substituting sedentary time and biomarker levels. After 5 years, replacing baseline 30-min of sedentary time per day with LPA or MVPA was associated with lower hs-TnT concentrations compared to baseline (-4%, 95% CI -8%, -1%; and − 2%, 95% CI -7%, 4%). Substitutions showed nonsignificant reductions in NT-proBNP but no consistent associations with other biomarkers.

Conclusions

Among overweight/obese individuals, replacing sedentary time with PA was associated with favorable 5-year changes of hs-TnT, but not other AF-related biomarkers.

Trial registration

The trial was registered on July 24, 2014, at ISRCTN (ISRCTN89898870) [www.isrctn.com/ISRCTN89898870 (accessed on December 10, 2025)].