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Objective <p>This study aims to compare the lesion characteristics of v-HPSD and conventional PC ablation modes and to quantitatively evaluate their dependence on impedance variation. </p> Methods <p>The study was performed using an ex vivo porcine heart model. Ablations in the v-HPSD group were carried out with a QDOT-MICRO™ catheter, whereas conventional power-control (PC) ablations employed a Thermocool-STSF® catheter, set at a fixed power of 40 W and terminated upon reaching an ablation index of 500. To study the effect of baseline impedance, it was dynamically adjusted to low, medium, and high preset levels by incorporating a sliding rheostat in series with the ablation circuit. </p> Results <p>Ablation lesions in the PC group were characterized by significantly smaller superficial and maximum diameters but greater depth compared to the v-HPSD group (Superficial diameter: 5.19±0.71 mm vs. 5.83±0.73 mm, <i>p</i>&lt;0.01; Maximum diameter: 7.04±0.95 mm vs. 7.79±0.96 mm, p&lt;0.01; Depth: 4.67±0.22 mm vs. 3.50±0.40 mm, <i>p</i>&lt;0.01). Although the mean lesion volume was larger in the PC group, this difference did not reach statistical significance (74.08±30.02 mm³ vs. 65.98±21.99 mm³, <i>p</i>=0.097).</p> <p>The ablation mode and impedance level demonstrated a significant interaction, which differentially affected the lesion parameters: highly significant for maximum depth and mean volume (<i>P</i> &lt; 0.001), significant for superficial diameter (P &lt; 0.05), and non-significant for maximum diameter (P = 0.587).</p> Conclusion <p>The v-HPSD mode exhibits superior adaptability, achieving comparable overall lesion volume in high-impedance settings by generating wider and depth-stable lesions, which underscores its enhanced performance predictability.</p>

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Lesion formation and impedance dependence of v-HPSD ablation (QDOT-MICRO™) versus conventional power-control (SmartTouch™ SF): a head-to-head comparison in an ex vivo porcine model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Jinhong Guo,
  • Yingjie Wang,
  • Meixue Jia,
  • Shuai Chen,
  • Bin Ning

摘要

Objective

This study aims to compare the lesion characteristics of v-HPSD and conventional PC ablation modes and to quantitatively evaluate their dependence on impedance variation.

Methods

The study was performed using an ex vivo porcine heart model. Ablations in the v-HPSD group were carried out with a QDOT-MICRO™ catheter, whereas conventional power-control (PC) ablations employed a Thermocool-STSF® catheter, set at a fixed power of 40 W and terminated upon reaching an ablation index of 500. To study the effect of baseline impedance, it was dynamically adjusted to low, medium, and high preset levels by incorporating a sliding rheostat in series with the ablation circuit.

Results

Ablation lesions in the PC group were characterized by significantly smaller superficial and maximum diameters but greater depth compared to the v-HPSD group (Superficial diameter: 5.19±0.71 mm vs. 5.83±0.73 mm, p<0.01; Maximum diameter: 7.04±0.95 mm vs. 7.79±0.96 mm, p<0.01; Depth: 4.67±0.22 mm vs. 3.50±0.40 mm, p<0.01). Although the mean lesion volume was larger in the PC group, this difference did not reach statistical significance (74.08±30.02 mm³ vs. 65.98±21.99 mm³, p=0.097).

The ablation mode and impedance level demonstrated a significant interaction, which differentially affected the lesion parameters: highly significant for maximum depth and mean volume (P < 0.001), significant for superficial diameter (P < 0.05), and non-significant for maximum diameter (P = 0.587).

Conclusion

The v-HPSD mode exhibits superior adaptability, achieving comparable overall lesion volume in high-impedance settings by generating wider and depth-stable lesions, which underscores its enhanced performance predictability.