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Background <p>The lipid accumulation product (LAP), which integrates waist circumference and triglyceride levels, is an effective indicator of excessive fat accumulation. This study aimed to investigate the association between LAP and the risk of incident stroke among adults aged 45&#xa0;years and older.</p> Methods <p>Using data from the China Health and Retirement Longitudinal Study (CHARLS), a total of 9,060 participants aged ≥ 45&#xa0;years without a prior history of stroke were included. LAP was categorized into quartiles (Q1–Q4). Cox proportional hazards models were applied to evaluate the association between LAP and incident stroke. Model 1 was adjusted for sex, age, and residence, while Model 2 was further adjusted for education level, smoking, alcohol consumption, body mass index, diabetes, hypertension, dyslipidemia, and history of cardiovascular disease.</p> Results <p>During follow-up, 1,300 incident stroke cases were identified among the 9,060 participants. Cox regression analysis showed that, compared with the lowest LAP quartile, participants in the higher quartile had a significantly increased risk of incident stroke. The association remained robust after excluding participants using lipid-lowering medications in sensitivity analyses. Subgroup analyses demonstrated consistent associations across age, sex, smoking status, alcohol consumption, hypertension, and diabetes. Kaplan–Meier curves across LAP quartiles indicated a significantly higher cumulative incidence of stroke in the high-LAP group.</p> Conclusions <p>Higher LAP was positively associated with an increased risk of incident stroke among adults aged 45&#xa0;years and older. LAP may serve as a complementary indicator for stroke risk screening in community populations.</p>

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Lipid accumulation product and its association between new onset stroke among middle age and elderly population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月21日

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  • Yan Xu,
  • Zhiqiang Li,
  • Si-Yi Wu,
  • Xiao-Ming Zhu

摘要

Background

The lipid accumulation product (LAP), which integrates waist circumference and triglyceride levels, is an effective indicator of excessive fat accumulation. This study aimed to investigate the association between LAP and the risk of incident stroke among adults aged 45 years and older.

Methods

Using data from the China Health and Retirement Longitudinal Study (CHARLS), a total of 9,060 participants aged ≥ 45 years without a prior history of stroke were included. LAP was categorized into quartiles (Q1–Q4). Cox proportional hazards models were applied to evaluate the association between LAP and incident stroke. Model 1 was adjusted for sex, age, and residence, while Model 2 was further adjusted for education level, smoking, alcohol consumption, body mass index, diabetes, hypertension, dyslipidemia, and history of cardiovascular disease.

Results

During follow-up, 1,300 incident stroke cases were identified among the 9,060 participants. Cox regression analysis showed that, compared with the lowest LAP quartile, participants in the higher quartile had a significantly increased risk of incident stroke. The association remained robust after excluding participants using lipid-lowering medications in sensitivity analyses. Subgroup analyses demonstrated consistent associations across age, sex, smoking status, alcohol consumption, hypertension, and diabetes. Kaplan–Meier curves across LAP quartiles indicated a significantly higher cumulative incidence of stroke in the high-LAP group.

Conclusions

Higher LAP was positively associated with an increased risk of incident stroke among adults aged 45 years and older. LAP may serve as a complementary indicator for stroke risk screening in community populations.