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Background <p>Low handgrip strength (HGS) predicts cardiovascular disease (CVD) risk, potentially via insulin resistance (IR). The triglyceride-glucose (TyG) index and its combinations with adiposity measures (TyG-BMI, TyG-WC, TyG-WHtR) enhance CVD prediction, but the prognostic value in low HGS populations is unknown.</p> Methods <p>This UK Biobank prospective cohort study analyzed 18,341 participants with low HGS (mean age 59.2&#xa0;years, 61.2% female). Multivariable Cox models assessed associations between TyG-related indices and incident CVD, coronary heart disease (CHD) and stroke. Subgroup and mediation analyses identified effect modifiers and pathways; sensitivity analyses validated result robustness.</p> Results <p>Over 13.4 median years, 2,666 CVD cases occurred. Per 1-SD increase, TyG, TyG-BMI, TyG-WC and TyG-WHtR were significantly associated with higher CVD incidence (adjusted HRs: 1.08, 1.13, 1.15, 1.15 respectively; all <i>p</i> &lt; 0.001). TyG-related indices showed significant interaction effects for CVD/CHD across subgroups including age, disease status and medication use. Mediation analyses indicated dyslipidemia, inflammation and IR mediated the associations.</p> Conclusions <p>Elevated TyG-related indices independently predict increased CVD and CHD incidence in individuals with low HGS, offering value for early risk identification and the development of preventive strategies.</p>

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Association of triglyceride-glucose related indices with cardiovascular diseases in individuals with low handgrip strength: a prospective cohort study of UK biobank

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月7日

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  • Chunfei Song,
  • Dachuan Guo,
  • Sha Chen,
  • Xiangzhen Ran,
  • Linsong Leng,
  • Yu Bai,
  • Jianmin Yang,
  • Zongwei Lin

摘要

Background

Low handgrip strength (HGS) predicts cardiovascular disease (CVD) risk, potentially via insulin resistance (IR). The triglyceride-glucose (TyG) index and its combinations with adiposity measures (TyG-BMI, TyG-WC, TyG-WHtR) enhance CVD prediction, but the prognostic value in low HGS populations is unknown.

Methods

This UK Biobank prospective cohort study analyzed 18,341 participants with low HGS (mean age 59.2 years, 61.2% female). Multivariable Cox models assessed associations between TyG-related indices and incident CVD, coronary heart disease (CHD) and stroke. Subgroup and mediation analyses identified effect modifiers and pathways; sensitivity analyses validated result robustness.

Results

Over 13.4 median years, 2,666 CVD cases occurred. Per 1-SD increase, TyG, TyG-BMI, TyG-WC and TyG-WHtR were significantly associated with higher CVD incidence (adjusted HRs: 1.08, 1.13, 1.15, 1.15 respectively; all p < 0.001). TyG-related indices showed significant interaction effects for CVD/CHD across subgroups including age, disease status and medication use. Mediation analyses indicated dyslipidemia, inflammation and IR mediated the associations.

Conclusions

Elevated TyG-related indices independently predict increased CVD and CHD incidence in individuals with low HGS, offering value for early risk identification and the development of preventive strategies.