Scholarlink

Background <p>Aortic Dissection (AD) is a life-threatening condition and one of the major causes of death in the U.S. Despite its clinical significance, trends in AD related mortality remain understudied. We aim to analyze nationwide mortality trends in AD in the U.S.</p> Methods <p>Data from CDC WONDER (1999–2024) identified U.S mortality rates in adults aged ≥ 25 years with AD (ICD-10: I71.0). Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Trends were analyzed using Joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC).</p> Results <p>From 1999 to 2024, a total of 115,449 deaths from AD were recorded. The AAMR increased from 2.1 in 1999 to 2.4 in 2024 (AAPC of 0.46; 95% CI: 0.31 to 0.61; <i>p</i> &lt; 0.001). Men had higher mortality than women (Overall AAMR: 2.62; <i>p</i> &lt; 0.001 vs. 1.45; <i>p</i> &lt; 0.001) (AAPC: 0.22; 95% CI: 0.05 to 0.39 vs. 0.61; 95% CI: 0.42 to 0.83) respectively. Racially, non-Hispanic (NH) Blacks demonstrated the greatest overall AAMR of 3.11. Regionally, AAMRs were highest in the Midwest (2.17) followed by the West (2.14). The urban areas had higher overall AAMRs than the rural areas (1.95, <i>p</i> = 0.27 vs. 1.90, <i>p</i> = 0.074). The majority of deaths occurred in medical facilities (88,976 deaths, 77.06%) and in older adults with CMR (5.8).</p> Conclusion <p>Mortality trends in AD increased from 1999 to 2024. Higher trends occurred in men, urban areas, Midwest region, NH Black population and medical facilities.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Trends and disparities in aortic dissection mortality in the united states: a retrospective analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月22日

查看全文
  • Mohamed Fawzi Hemida,
  • Alyaa Ahmed Ibrahim,
  • Nafila Zeeshan,
  • Mohammad Rayyan Faisal,
  • Krish Patel,
  • Mirna Hussein,
  • Arwa Khaled Dessouky,
  • Maryam Saghir,
  • Eshal Saghir,
  • Muhammad Raza Sarfraz,
  • Zahin Shahriar,
  • Maha Al Haj Kadour,
  • Abdullah Farahat Elbanna,
  • Mohamed Ahmed Rahma Dawelbait,
  • Muhammad Faizan Ali,
  • Ahmad M. Abdelkhalek,
  • Rana Sayed,
  • Khaled Ali

摘要

Background

Aortic Dissection (AD) is a life-threatening condition and one of the major causes of death in the U.S. Despite its clinical significance, trends in AD related mortality remain understudied. We aim to analyze nationwide mortality trends in AD in the U.S.

Methods

Data from CDC WONDER (1999–2024) identified U.S mortality rates in adults aged ≥ 25 years with AD (ICD-10: I71.0). Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Trends were analyzed using Joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC).

Results

From 1999 to 2024, a total of 115,449 deaths from AD were recorded. The AAMR increased from 2.1 in 1999 to 2.4 in 2024 (AAPC of 0.46; 95% CI: 0.31 to 0.61; p < 0.001). Men had higher mortality than women (Overall AAMR: 2.62; p < 0.001 vs. 1.45; p < 0.001) (AAPC: 0.22; 95% CI: 0.05 to 0.39 vs. 0.61; 95% CI: 0.42 to 0.83) respectively. Racially, non-Hispanic (NH) Blacks demonstrated the greatest overall AAMR of 3.11. Regionally, AAMRs were highest in the Midwest (2.17) followed by the West (2.14). The urban areas had higher overall AAMRs than the rural areas (1.95, p = 0.27 vs. 1.90, p = 0.074). The majority of deaths occurred in medical facilities (88,976 deaths, 77.06%) and in older adults with CMR (5.8).

Conclusion

Mortality trends in AD increased from 1999 to 2024. Higher trends occurred in men, urban areas, Midwest region, NH Black population and medical facilities.

Graphical Abstract