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Background <p>Ethnic disparities in heart failure (HF) outcomes have been widely documented, but data from countries with universal healthcare systems, such as Israel, are limited. This study assessed whether long-term clinical outcomes differ between Jewish and non-Jewish patients hospitalized for acute decompensated heart failure (ADHF).</p> Methods <p><?tk 2?>We conducted a retrospective cohort study of adults hospitalized with ADHF at a tertiary medical center in Israel between 2007 and 2017. Patients were categorized by self-reported ethnicity. Baseline characteristics, in-hospital treatments, discharge medications, and clinical outcomes were compared. The primary outcome was 5-year all-cause mortality. Secondary outcomes included in-hospital mortality, 30-day readmission, 30-day mortality, 1-year mortality, and treatment patterns.</p> Results <p>Of 7,199 patients, 90.3% were Jewish and 9.7% non-Jewish. Non-Jewish patients were younger (median age 74 vs. 80 years, <i>p</i> &lt; 0.001) and had higher rates of smoking and obesity. Most comorbidities, procedures, and discharge therapies were comparable. Unadjusted short-term outcomes were similar between groups. Although unadjusted 5-year survival appeared higher in non-Jews (<i>p</i> = 0.002), multivariable Cox regression showed that non-Jewish ethnicity was independently associated with increased 5-year mortality (HR 1.13, 95% CI 1.02–1.25, <i>p</i> = 0.021).</p> Conclusions <p>In this large cohort of patients hospitalized with ADHF in Israel, non-Jewish ethnicity was independently associated with worse long-term survival despite younger age and similar in-hospital care. These findings underscore the need for targeted follow-up strategies to mitigate ethnic disparities in chronic HF outcomes.</p>

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Impact of ethnicity on long-term mortality following hospitalization for acute decompensated heart failure: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Gil Marcus,
  • Mohameed Daoud,
  • Shiri L. Maymon,
  • Ido Minha,
  • Eran Kalmanovich,
  • Gil Moravsky,
  • Avishay Grupper,
  • Shmuel Fuchs,
  • Sa’ar Minha

摘要

Background

Ethnic disparities in heart failure (HF) outcomes have been widely documented, but data from countries with universal healthcare systems, such as Israel, are limited. This study assessed whether long-term clinical outcomes differ between Jewish and non-Jewish patients hospitalized for acute decompensated heart failure (ADHF).

Methods

We conducted a retrospective cohort study of adults hospitalized with ADHF at a tertiary medical center in Israel between 2007 and 2017. Patients were categorized by self-reported ethnicity. Baseline characteristics, in-hospital treatments, discharge medications, and clinical outcomes were compared. The primary outcome was 5-year all-cause mortality. Secondary outcomes included in-hospital mortality, 30-day readmission, 30-day mortality, 1-year mortality, and treatment patterns.

Results

Of 7,199 patients, 90.3% were Jewish and 9.7% non-Jewish. Non-Jewish patients were younger (median age 74 vs. 80 years, p < 0.001) and had higher rates of smoking and obesity. Most comorbidities, procedures, and discharge therapies were comparable. Unadjusted short-term outcomes were similar between groups. Although unadjusted 5-year survival appeared higher in non-Jews (p = 0.002), multivariable Cox regression showed that non-Jewish ethnicity was independently associated with increased 5-year mortality (HR 1.13, 95% CI 1.02–1.25, p = 0.021).

Conclusions

In this large cohort of patients hospitalized with ADHF in Israel, non-Jewish ethnicity was independently associated with worse long-term survival despite younger age and similar in-hospital care. These findings underscore the need for targeted follow-up strategies to mitigate ethnic disparities in chronic HF outcomes.