Scholarlink

Background <p>Functional recovery after cardiac events is heterogeneous, with up to 40% of patients showing limited improvement despite standardized rehabilitation. Current assessment tools demonstrate modest accuracy (~ 61%) and rarely capture the multidimensional aspects of functional status. This study aimed to develop and internally validate a pragmatic bedside functional stratification tool for patients entering cardiac rehabilitation.</p> Methods <p>We conducted a cross-sectional study of 80 patients (mean age 72.7 ± 5.2 years, 65% male) at rehabilitation intake. Four routinely available parameters were assessed: age, six-minute walk test (6MWT), Timed Up and Go (TUG), and the Edmonton Frail Scale (EFS). Each was categorized into four levels (0–3 points), yielding a composite score of 0–12. Patients were stratified as Low (0–3), Moderate (4–6), High (7–9), or Very High (10–12) functional impairment. Internal validation employed bootstrap resampling (<i>n</i> = 1000).</p> Results <p>Functional capacity declined progressively across categories: 6MWT decreased from 364.3 ± 75.7&#xa0;m (Low Impairment) to 185.2 ± 32.9&#xa0;m (Very High Impairment), and TUG increased from 6.9 ± 1.0&#xa0;s to 14.2 ± 2.8&#xa0;s (all <i>p</i> &lt; 0.001). The composite score correlated strongly with functional performance (<i>r</i> = − 0.75, <i>p</i> &lt; 0.001) and demonstrated excellent discrimination (AUC 0.93, 95% CI 0.87–0.97), outperforming individual measures. Bootstrap validation confirmed stability.</p> Conclusions <p>We propose a simple, multidomain bedside score requiring ~ 25&#xa0;min and no specialized equipment. This tool enables functional stratification at rehabilitation intake, supports personalized care, and facilitates matching rehabilitation pathways to baseline functional status. External validation is warranted.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development and validation of a multidimensional tool for baseline functional phenotyping in cardiac rehabilitation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月4日

查看全文
  • Binbin Huang,
  • Qian Zhang,
  • Yang Wang,
  • Chao Liu,
  • Hongwei Li,
  • Deqiang Wang,
  • Wei Li

摘要

Background

Functional recovery after cardiac events is heterogeneous, with up to 40% of patients showing limited improvement despite standardized rehabilitation. Current assessment tools demonstrate modest accuracy (~ 61%) and rarely capture the multidimensional aspects of functional status. This study aimed to develop and internally validate a pragmatic bedside functional stratification tool for patients entering cardiac rehabilitation.

Methods

We conducted a cross-sectional study of 80 patients (mean age 72.7 ± 5.2 years, 65% male) at rehabilitation intake. Four routinely available parameters were assessed: age, six-minute walk test (6MWT), Timed Up and Go (TUG), and the Edmonton Frail Scale (EFS). Each was categorized into four levels (0–3 points), yielding a composite score of 0–12. Patients were stratified as Low (0–3), Moderate (4–6), High (7–9), or Very High (10–12) functional impairment. Internal validation employed bootstrap resampling (n = 1000).

Results

Functional capacity declined progressively across categories: 6MWT decreased from 364.3 ± 75.7 m (Low Impairment) to 185.2 ± 32.9 m (Very High Impairment), and TUG increased from 6.9 ± 1.0 s to 14.2 ± 2.8 s (all p < 0.001). The composite score correlated strongly with functional performance (r = − 0.75, p < 0.001) and demonstrated excellent discrimination (AUC 0.93, 95% CI 0.87–0.97), outperforming individual measures. Bootstrap validation confirmed stability.

Conclusions

We propose a simple, multidomain bedside score requiring ~ 25 min and no specialized equipment. This tool enables functional stratification at rehabilitation intake, supports personalized care, and facilitates matching rehabilitation pathways to baseline functional status. External validation is warranted.