Scholarlink

Background <p>Previous studies have demonstrated greater lumen eccentricity and asymmetry with BRS compared to DES, but evidence regarding their expansion performance in complex lesions characterized by eccentric morphology or calcification remains scarce. This study aimed to compare and analyze the acute device performance of bioresorbable scaffolds (BRS) versus drug-eluting metallic stents (DES) using intravascular ultrasound (IVUS), and their expansion characteristics in eccentric and calcified lesions.</p> Methods <p>IVUS analysis was performed pre- and post-procedure in 184 patients (48 BRS and 136 DES). Plaque eccentricity was quantified during pre-procedural using the plaque eccentricity index (PEI), with lesions stratified by calcification severity (no/mild: ≤90°; moderate/severe: &gt;90° arc), while post-procedural device expansion performance was evaluated through three IVUS parameters including asymmetry index (AI), expansion ratio (ER) and eccentricity index (SEI).</p> Results <p>Pre-procedural PEI demonstrated predictive value for post-procedural SEI and AI in both groups, yielding Areas Under the Curve (AUCs) of 0.811 and 0.773 for BRS, and 0.747 and 0.713 for DES. At high PEI, BRS showed significantly lower SEI than DES (0.87 vs. 0.91, <i>P</i> &lt; 0.001). Moderate/severe calcification significantly increased AI in both BRS (0.36 vs. 0.32, <i>P</i> = 0.029) and DES (0.34 vs. 0.31, <i>P</i> = 0.025).</p> Conclusions <p>Eccentric distribution of plaque affects symmetry and uniformity of device expansion, and device eccentricity was more affected by the degree of pre-procedural plaque eccentricity in BRS than in DES. Moreover, calcified plaque further exacerbated post-procedural device asymmetry.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of eccentric and calcified plaque on bioresorbable scaffold and drug-eluting metallic stent expansion characteristics: a comparative intravascular ultrasound study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月12日

查看全文
  • Wenbo Sun,
  • Chengpeng Liu,
  • Jiasheng Yin,
  • Chenguang Li,
  • Hao Lu,
  • Juying Qian,
  • Zhiqiang Pei,
  • Li Shen,
  • Junbo Ge

摘要

Background

Previous studies have demonstrated greater lumen eccentricity and asymmetry with BRS compared to DES, but evidence regarding their expansion performance in complex lesions characterized by eccentric morphology or calcification remains scarce. This study aimed to compare and analyze the acute device performance of bioresorbable scaffolds (BRS) versus drug-eluting metallic stents (DES) using intravascular ultrasound (IVUS), and their expansion characteristics in eccentric and calcified lesions.

Methods

IVUS analysis was performed pre- and post-procedure in 184 patients (48 BRS and 136 DES). Plaque eccentricity was quantified during pre-procedural using the plaque eccentricity index (PEI), with lesions stratified by calcification severity (no/mild: ≤90°; moderate/severe: >90° arc), while post-procedural device expansion performance was evaluated through three IVUS parameters including asymmetry index (AI), expansion ratio (ER) and eccentricity index (SEI).

Results

Pre-procedural PEI demonstrated predictive value for post-procedural SEI and AI in both groups, yielding Areas Under the Curve (AUCs) of 0.811 and 0.773 for BRS, and 0.747 and 0.713 for DES. At high PEI, BRS showed significantly lower SEI than DES (0.87 vs. 0.91, P < 0.001). Moderate/severe calcification significantly increased AI in both BRS (0.36 vs. 0.32, P = 0.029) and DES (0.34 vs. 0.31, P = 0.025).

Conclusions

Eccentric distribution of plaque affects symmetry and uniformity of device expansion, and device eccentricity was more affected by the degree of pre-procedural plaque eccentricity in BRS than in DES. Moreover, calcified plaque further exacerbated post-procedural device asymmetry.