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Background <p>Primary cardiac angiosarcoma is rare and highly invasive to myocardial tissue and prone to metastasis. Surgery is an effective treatment, but it is difficult and risky. Postoperative therapy could improve survival rate, but specific regimens are controversial.</p> Case presentation <p>We herein demonstrated the management experience of a patient with primary cardiac angiosarcoma at 19 weeks of pregnancy, which can be used as a reference for other patients. She underwent surgical R1 resection during pregnancy, but the fetus aborted spontaneously 4&#xa0;h after surgery. Under the care of our multidisciplinary team, she also received radiotherapy, chemotherapy, and targeted therapy. After that, she was evaluated as stable disease at 14th months after surgery. She developed multiple bone metastases 16th months after surgery and finally died in the 18th month after surgery.</p> Conclusion <p>Surgical resection of cardiac angiosarcoma should remove as much tumor tissue as possible. Chemotherapy and targeted therapy are beneficial in shrinking tumors and control disease progression.</p>

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Multidisciplinary treatment for primary cardiac angiosarcoma: a case report and overview of the literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月12日

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  • Zhenzhong Wang,
  • Shanwen Pang,
  • Muhammad Khalid,
  • Linbin Hua,
  • Junqiang Qiu,
  • Yuxin Li,
  • Yingjie Ke,
  • Junfei Zhao,
  • Songxi Xie,
  • Huanlei Huang

摘要

Background

Primary cardiac angiosarcoma is rare and highly invasive to myocardial tissue and prone to metastasis. Surgery is an effective treatment, but it is difficult and risky. Postoperative therapy could improve survival rate, but specific regimens are controversial.

Case presentation

We herein demonstrated the management experience of a patient with primary cardiac angiosarcoma at 19 weeks of pregnancy, which can be used as a reference for other patients. She underwent surgical R1 resection during pregnancy, but the fetus aborted spontaneously 4 h after surgery. Under the care of our multidisciplinary team, she also received radiotherapy, chemotherapy, and targeted therapy. After that, she was evaluated as stable disease at 14th months after surgery. She developed multiple bone metastases 16th months after surgery and finally died in the 18th month after surgery.

Conclusion

Surgical resection of cardiac angiosarcoma should remove as much tumor tissue as possible. Chemotherapy and targeted therapy are beneficial in shrinking tumors and control disease progression.