Scholarlink

Background <p>As a major modifiable risk factor for cardiovascular diseases worldwide, hypertension novel biomarkers that integrate inflammatory and metabolic pathways may improve risk stratification. The association between the red cell distribution width-to-albumin ratio (RAR), a newly identified inflammatory biomarker, and hypertension has not been systematically evaluated in population-based studies.</p> Methods <p>A cross-sectional study included 7,878 adults. Weighted multivariable logistic regression and threshold effect models were employed to analyze nonlinear associations, with subgroup analyses exploring heterogeneity.</p> Results <p>RAR showed a linear positive association with hypertension (adjusted OR = 1.26 per unit, 95%CI:1.09–1.44, <i>P</i> &lt; 0.05), a threshold effect was observed. Piecewise regression revealed a significant association when RAR ≥ 3.4, with a higher hypertension prevalence (adjusted OR = 1.34, 95%CI:1.17–1.54), while no association existed below 3.4 (<i>P</i> = 0.408). For those aged 40–60 years, the inflection point was RAR = 3.92 (95%CI:3.76–4.51), with stronger associations observed below this threshold (OR = 1.80, 95%CI:1.33–2.43). Subgroup analyses revealed significant heterogeneity: diabetics exhibited stronger associations than non-diabetics (interaction <i>P</i> = 0.02), and enhanced associations were also observed in females and individuals aged &gt; 40 years.</p> Conclusion <p>This study confirmed a linear positive correlation between red blood cell distribution width and albumin ratio (RAR) and the prevalence of hypertension, RAR ≥ 3.4 was associated with higher hypertension prevalence and may help identify high-risk subgroups, particularly among diabetics, but its predictive value warrants validation through prospective cohort studies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Red cell distribution width-to-albumin ratio and hypertension risk: age-specific threshold effects identified in the 2017–2020 NHANES U.S. Adult population

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月9日

查看全文
  • Zihao Zhao,
  • Yuhong Ma,
  • Weizhong Huangfu

摘要

Background

As a major modifiable risk factor for cardiovascular diseases worldwide, hypertension novel biomarkers that integrate inflammatory and metabolic pathways may improve risk stratification. The association between the red cell distribution width-to-albumin ratio (RAR), a newly identified inflammatory biomarker, and hypertension has not been systematically evaluated in population-based studies.

Methods

A cross-sectional study included 7,878 adults. Weighted multivariable logistic regression and threshold effect models were employed to analyze nonlinear associations, with subgroup analyses exploring heterogeneity.

Results

RAR showed a linear positive association with hypertension (adjusted OR = 1.26 per unit, 95%CI:1.09–1.44, P < 0.05), a threshold effect was observed. Piecewise regression revealed a significant association when RAR ≥ 3.4, with a higher hypertension prevalence (adjusted OR = 1.34, 95%CI:1.17–1.54), while no association existed below 3.4 (P = 0.408). For those aged 40–60 years, the inflection point was RAR = 3.92 (95%CI:3.76–4.51), with stronger associations observed below this threshold (OR = 1.80, 95%CI:1.33–2.43). Subgroup analyses revealed significant heterogeneity: diabetics exhibited stronger associations than non-diabetics (interaction P = 0.02), and enhanced associations were also observed in females and individuals aged > 40 years.

Conclusion

This study confirmed a linear positive correlation between red blood cell distribution width and albumin ratio (RAR) and the prevalence of hypertension, RAR ≥ 3.4 was associated with higher hypertension prevalence and may help identify high-risk subgroups, particularly among diabetics, but its predictive value warrants validation through prospective cohort studies.