Scholarlink

Background <p>The Stress Hyperglycemia Ratio (SHR), which serves as an indicator of blood glucose variability in response to acute illness or injury, has been established as a predictor of long-term prognosis for various diseases, particularly those affecting cardiovascular health. However, the relationship between SHR and patients presenting with acute coronary syndrome (ACS) in conjunction with chronic kidney disease (CKD) remains to be fully elucidated.</p> Methods <p>From January 2013 to December 2019, this study enrolled a total of 465 patients with ACS complicated by CKD at the First Affiliated Hospital of Wenzhou Medical University. Fasting blood glucose (FBG), glycated hemoglobin, and other relevant parameters were recorded for these patients, and they were followed up for major adverse cardiovascular events (MACE).</p> Results <p>A total of 465 patients were ultimately included, of whom 97 experienced MACE during the follow-up period. Multivariate Cox regression analysis revealed that SHR is an independent risk factor for patients with ACS complicated by CKD. The group with elevated SHR exhibited the highest incidence of MACE, and a nonlinear “J-shaped” relationship was observed between SHR and the risk of MACE, with an inflection point at 0.84. However, no significant heterogeneity was noted in the subgroup analysis. The inclusion of SHR enhances the predictive capability of the GRACE score.</p> Conclusion <p>SHR serves as a reliable indicator of long-term outcomes in patients with ACS and CKD. Additionally, SHR enhances the prognostic accuracy of the GRACE score for ACS-CKD patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Stress hyperglycemia ratio and its correlation with long-term prognosis in ACS patients with chronic kidney disease: a retrospective study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月4日

查看全文
  • Ruihao Jiang,
  • Yiyang Li,
  • Lin Cheng,
  • Weicheng Ni,
  • Qingwei Ni,
  • Jianhan Zhu,
  • Ken Lin,
  • Jiayu Ke,
  • Zhan Gao,
  • Hao Zhou

摘要

Background

The Stress Hyperglycemia Ratio (SHR), which serves as an indicator of blood glucose variability in response to acute illness or injury, has been established as a predictor of long-term prognosis for various diseases, particularly those affecting cardiovascular health. However, the relationship between SHR and patients presenting with acute coronary syndrome (ACS) in conjunction with chronic kidney disease (CKD) remains to be fully elucidated.

Methods

From January 2013 to December 2019, this study enrolled a total of 465 patients with ACS complicated by CKD at the First Affiliated Hospital of Wenzhou Medical University. Fasting blood glucose (FBG), glycated hemoglobin, and other relevant parameters were recorded for these patients, and they were followed up for major adverse cardiovascular events (MACE).

Results

A total of 465 patients were ultimately included, of whom 97 experienced MACE during the follow-up period. Multivariate Cox regression analysis revealed that SHR is an independent risk factor for patients with ACS complicated by CKD. The group with elevated SHR exhibited the highest incidence of MACE, and a nonlinear “J-shaped” relationship was observed between SHR and the risk of MACE, with an inflection point at 0.84. However, no significant heterogeneity was noted in the subgroup analysis. The inclusion of SHR enhances the predictive capability of the GRACE score.

Conclusion

SHR serves as a reliable indicator of long-term outcomes in patients with ACS and CKD. Additionally, SHR enhances the prognostic accuracy of the GRACE score for ACS-CKD patients.