Scholarlink

Background <p>Contrast-induced nephropathy (CIN) is a significant complication in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The role of the stress hyperglycemia ratio (SHR) as a predictor of CIN and mortality in these patients remains unclear and warrants investigation.</p> Objective <p>To assess the relationship between SHR and CIN, as well as its impact on short-term mortality in ACS patients undergoing PCI.</p> Methods <p>We conducted a retrospective cohort study using the MIMIC-IV database, including 552 ACS patients. SHR was calculated as the ratio of admission glucose to estimated average glucose from hemoglobin A1c. CIN was defined as a ≥ 0.5 mg/dL or ≥ 25% increase in serum creatinine within 48 h of PCI. Logistic regression and spline models were used to analyze the association between SHR and CIN, while Kaplan–Meier curves assessed 30-day mortality.</p> Results <p>Higher SHR levels were independently associated with increased CIN risk (OR 2.36, 95% CI: 1.56–3.57, <i>P</i> &lt; 0.0001). A J-shaped relationship was observed, with CIN risk rising sharply when SHR exceeded 1.06. SHR was also a predictor of higher 30-day mortality (<i>P</i> &lt; 0.0001). Subgroup analysis revealed a stronger SHR-CIN association in non-diabetic patients.</p> Conclusion <p>SHR is an independent predictor of CIN and short-term mortality in ACS patients undergoing PCI. It offers potential for risk stratification and clinical decision-making, especially in non-diabetic patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between stress hyperglycemia ratio and contrast-induced nephropathy in ACS patients undergoing PCI: a retrospective cohort study from the MIMIC-IV database

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月25日

查看全文
  • Yanlong Zhao,
  • Yuanyuan Zhao,
  • Shuai Wang,
  • Zhenxing Fan,
  • Yanling Wang,
  • Fangyan Liu,
  • Zhi Liu

摘要

Background

Contrast-induced nephropathy (CIN) is a significant complication in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The role of the stress hyperglycemia ratio (SHR) as a predictor of CIN and mortality in these patients remains unclear and warrants investigation.

Objective

To assess the relationship between SHR and CIN, as well as its impact on short-term mortality in ACS patients undergoing PCI.

Methods

We conducted a retrospective cohort study using the MIMIC-IV database, including 552 ACS patients. SHR was calculated as the ratio of admission glucose to estimated average glucose from hemoglobin A1c. CIN was defined as a ≥ 0.5 mg/dL or ≥ 25% increase in serum creatinine within 48 h of PCI. Logistic regression and spline models were used to analyze the association between SHR and CIN, while Kaplan–Meier curves assessed 30-day mortality.

Results

Higher SHR levels were independently associated with increased CIN risk (OR 2.36, 95% CI: 1.56–3.57, P < 0.0001). A J-shaped relationship was observed, with CIN risk rising sharply when SHR exceeded 1.06. SHR was also a predictor of higher 30-day mortality (P < 0.0001). Subgroup analysis revealed a stronger SHR-CIN association in non-diabetic patients.

Conclusion

SHR is an independent predictor of CIN and short-term mortality in ACS patients undergoing PCI. It offers potential for risk stratification and clinical decision-making, especially in non-diabetic patients.