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Background <p>Sevoflurane and desflurane are routinely used volatile anaesthetics in balanced general anaesthesia, but their elimination time from the human body may be underestimated.</p> Methods <p>Levels of sevoflurane and desflurane in end-tidal exhaled breath and ambient room air were measured pre- and post-operatively using calibrated Gas Chromatography-Ion Mobility Spectrometry (GC-IMS). Exponential regressions were applied to determine half-lives and to estimate the time required for exhaled breath concentrations to return to baseline (preoperative) levels.</p> Results <p>Thirty-nine surgical patients (aged 18–87 years) were enrolled. A total of 526 exhaled breath and 263 ambient room air samples were analysed. In ASA II patients, the median elimination half-life was 6.5&#xa0;h (IQR: 5.4–10.1) for sevoflurane and 12.8&#xa0;h (IQR: 7.4–18.7) for desflurane. The estimated time for exhaled breath concentrations to return to preoperative values ranged from 66 to 737&#xa0;h for sevoflurane and 135 to 593&#xa0;h for desflurane.</p> Conclusion <p>GC-IMS detected trace concentrations of exhaled sevoflurane and desflurane well beyond the immediate postoperative period. These findings suggest prolonged low-level elimination, although the clinical relevance of this extended washout remains unclear.</p>

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Washout characteristics of sevoflurane and desflurane in surgical patients: a prospective observational study using gas chromatography - ion mobility spectrometry

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月1日

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  • Jonas Dunz,
  • Raffaella Fantin,
  • Valeria Volk,
  • Florentin Weiss,
  • Veronika Ruzsanyi,
  • Chris A. Mayhew,
  • Wolfgang Lederer

摘要

Background

Sevoflurane and desflurane are routinely used volatile anaesthetics in balanced general anaesthesia, but their elimination time from the human body may be underestimated.

Methods

Levels of sevoflurane and desflurane in end-tidal exhaled breath and ambient room air were measured pre- and post-operatively using calibrated Gas Chromatography-Ion Mobility Spectrometry (GC-IMS). Exponential regressions were applied to determine half-lives and to estimate the time required for exhaled breath concentrations to return to baseline (preoperative) levels.

Results

Thirty-nine surgical patients (aged 18–87 years) were enrolled. A total of 526 exhaled breath and 263 ambient room air samples were analysed. In ASA II patients, the median elimination half-life was 6.5 h (IQR: 5.4–10.1) for sevoflurane and 12.8 h (IQR: 7.4–18.7) for desflurane. The estimated time for exhaled breath concentrations to return to preoperative values ranged from 66 to 737 h for sevoflurane and 135 to 593 h for desflurane.

Conclusion

GC-IMS detected trace concentrations of exhaled sevoflurane and desflurane well beyond the immediate postoperative period. These findings suggest prolonged low-level elimination, although the clinical relevance of this extended washout remains unclear.