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Background <p>Oxygen consumption (VO₂) is a core element of hemodynamic physiology and the metabolic counterpart to oxygen delivery. Modern anesthesia machines enable real-time intraoperative VO₂ estimation, yet its relationship with preoperative metabolic capacity, as characterized by cardiopulmonary exercise testing (CPET), has not been directly examined.</p> Methods <p>This study analyzed preoperative CPET and intraoperative data from adult patients ≥ 20 undergoing lung resection under general anesthesia. Intraoperative VO₂ was estimated from minute ventilation and inspired and end-tidal oxygen fractions. Preoperative and intraoperative VO₂ were summarized, and associations between baseline VO₂ and intraoperative suppression were assessed.</p> Results <p>Data from 32 patients were analyzed. Preoperative VO₂ at rest, anaerobic threshold, and peak exercise were 1.6 ± 0.4, 5.1 ± 1.9, and 6.1 ± 1.7 metabolic equivalents (METs), respectively. The reduction from resting to intraoperative VO₂ (–29.0 ± 19.4%) showed a strong correlation with resting VO₂ (<i>r</i> = 0.770, <i>p</i> &lt; 0.001). Consequently, regardless of preoperative resting VO₂, intraoperative VO₂ converged to a relatively narrow range, averaging 1.1 ± 0.2 METs.</p> Conclusions <p>In patients undergoing lung resection, intraoperative VO₂ converged to approximately 1 MET under general anesthesia, largely independent of preoperative resting metabolism. The clinical implications of this observation remain unclear and warrant investigation in larger prospective studies incorporating concurrent measurements of oxygen delivery and clinical outcomes.</p>

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Preoperative and intraoperative oxygen consumption in patients undergoing lung resection surgery: a retrospective study using cardiopulmonary exercise test and intraoperative data

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月14日

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  • Chahyun Oh,
  • Sangil Park,
  • Sanghun Lee,
  • Yooyoung Chong,
  • Sung Joon Han,
  • Min-Woong Kang,
  • Boohwi Hong

摘要

Background

Oxygen consumption (VO₂) is a core element of hemodynamic physiology and the metabolic counterpart to oxygen delivery. Modern anesthesia machines enable real-time intraoperative VO₂ estimation, yet its relationship with preoperative metabolic capacity, as characterized by cardiopulmonary exercise testing (CPET), has not been directly examined.

Methods

This study analyzed preoperative CPET and intraoperative data from adult patients ≥ 20 undergoing lung resection under general anesthesia. Intraoperative VO₂ was estimated from minute ventilation and inspired and end-tidal oxygen fractions. Preoperative and intraoperative VO₂ were summarized, and associations between baseline VO₂ and intraoperative suppression were assessed.

Results

Data from 32 patients were analyzed. Preoperative VO₂ at rest, anaerobic threshold, and peak exercise were 1.6 ± 0.4, 5.1 ± 1.9, and 6.1 ± 1.7 metabolic equivalents (METs), respectively. The reduction from resting to intraoperative VO₂ (–29.0 ± 19.4%) showed a strong correlation with resting VO₂ (r = 0.770, p < 0.001). Consequently, regardless of preoperative resting VO₂, intraoperative VO₂ converged to a relatively narrow range, averaging 1.1 ± 0.2 METs.

Conclusions

In patients undergoing lung resection, intraoperative VO₂ converged to approximately 1 MET under general anesthesia, largely independent of preoperative resting metabolism. The clinical implications of this observation remain unclear and warrant investigation in larger prospective studies incorporating concurrent measurements of oxygen delivery and clinical outcomes.