Scholarlink

Purpose <p>Magnesium plays a role in various physiological processes and has been used for treatment and prevention of diseases affecting different organ systems. Magnesium sulfate has been proposed as an adjuvant for anesthesia, but its efficacy remains debated due to conflicting findings. The present study explored the analgesic effects of different routines of magnesium sulfate administration under three common perioperative situations in rats.</p> Methods <p>The study tested several doses of magnesium sulfate (e.g., 30&#xa0;mg/kg, 50&#xa0;mg/kg) in rats under different perioperative conditions: (1) perineural co-administration of magnesium sulfate with lidocaine, (2) intraperitoneally magnesium sulfate pre-administration before lidocaine nerve block, and (3) systemic magnesium sulfate given before or after plantar incision surgery. Sensory/motor blockade duration and mechanical pain thresholds were assessed.</p> Results <p>When magnesium sulfate is used as an adjunct to lidocaine, all doses of magnesium sulfate can reduce the sciatic nerve block caused by lidocaine. However, when administered via intraperitoneal injection, lower concentrations of magnesium sulfate (e.g., 30&#xa0;mg/kg, 50&#xa0;mg/kg) enhance the blocking effect of lidocaine, while higher concentrations (e.g., 150&#xa0;mg/kg, 300&#xa0;mg/kg) show no significant additional benefit. In a rat plantar incision model, both preoperative and postoperative intraperitoneal administration of magnesium sulfate effectively alleviated postoperative pain, with the 150&#xa0;mg/kg dose yielding the most pronounced effect.</p> Conclusion <p>Magnesium sulfate exhibits route-dependent effects: while it attenuates lidocaine-induced nerve blockade when administered locally, it enhances blockade duration and provides significant analgesia when given systemically. These findings implies that magnesium sulfate paves the way for designing safer nerve block protocols when administered locally, while its systemic application translates into more prolonged and superior postoperative analgesia, thereby reducing opioid consumption and facilitating patient recovery.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Systemic administration of magnesium sulfate enhances lidocaine-induced sciatic nerve block and exerts analgesic effects in postsurgical pain in rats

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月21日

查看全文
  • Zhong-Mou Shi,
  • Yun-Fei Lu,
  • Yu Sun,
  • Lu Chen,
  • Fei Yang,
  • Xiao-Zhi Wu

摘要

Purpose

Magnesium plays a role in various physiological processes and has been used for treatment and prevention of diseases affecting different organ systems. Magnesium sulfate has been proposed as an adjuvant for anesthesia, but its efficacy remains debated due to conflicting findings. The present study explored the analgesic effects of different routines of magnesium sulfate administration under three common perioperative situations in rats.

Methods

The study tested several doses of magnesium sulfate (e.g., 30 mg/kg, 50 mg/kg) in rats under different perioperative conditions: (1) perineural co-administration of magnesium sulfate with lidocaine, (2) intraperitoneally magnesium sulfate pre-administration before lidocaine nerve block, and (3) systemic magnesium sulfate given before or after plantar incision surgery. Sensory/motor blockade duration and mechanical pain thresholds were assessed.

Results

When magnesium sulfate is used as an adjunct to lidocaine, all doses of magnesium sulfate can reduce the sciatic nerve block caused by lidocaine. However, when administered via intraperitoneal injection, lower concentrations of magnesium sulfate (e.g., 30 mg/kg, 50 mg/kg) enhance the blocking effect of lidocaine, while higher concentrations (e.g., 150 mg/kg, 300 mg/kg) show no significant additional benefit. In a rat plantar incision model, both preoperative and postoperative intraperitoneal administration of magnesium sulfate effectively alleviated postoperative pain, with the 150 mg/kg dose yielding the most pronounced effect.

Conclusion

Magnesium sulfate exhibits route-dependent effects: while it attenuates lidocaine-induced nerve blockade when administered locally, it enhances blockade duration and provides significant analgesia when given systemically. These findings implies that magnesium sulfate paves the way for designing safer nerve block protocols when administered locally, while its systemic application translates into more prolonged and superior postoperative analgesia, thereby reducing opioid consumption and facilitating patient recovery.