Scholarlink

Purpose <p>Preoperative anxiety is common in pediatric surgical patients and may delay postoperative recovery. Conventional intranasal or nebulized dexmedetomidine often requires off-label dilution and manual assembly, which can lead to dosing inconsistency and variable mucosal absorption. We evaluated a novel dexmedetomidine nasal spray in children undergoing laparoscopic inguinal hernia repair.</p> Methods <p>In this study, 100 children aged 2–6 years scheduled for laparoscopic high ligation of the hernia sac for indirect inguinal hernia received either dexmedetomidine spray (Group D, <i>n</i> = 50) or saline (Group C, <i>n</i> = 50) 30&#xa0;min before anesthesia. Primary outcome was time to first flatus; secondary outcomes included time to first defecation, time to tolerated oral intake, I-FEED scores on postoperative days 1–3, preoperative anxiety in children and parents, postoperative pain, and behavioral changes.</p> Results <p>Group D showed significantly shorter time to first flatus (14.61 ± 4.19&#xa0;h vs. 17.57 ± 5.96&#xa0;h, <i>P</i> = 0.006), defecation (23.94 ± 7.22&#xa0;h vs. 29.70 ± 7.63&#xa0;h, <i>P</i> &lt; 0.001) and time to tolerated oral intake (12.82 ± 5.94&#xa0;h vs. 14.92 ± 7.02&#xa0;h, <i>P</i> = 0.047). FLACC scores and I-FEED scores were also lower on day 1 (<i>P</i> = 0.015, <i>P</i> = 0.022, respectively). Intranasal dexmedetomidine attenuates preoperative anxiety in both children and parents and facilitates smoother separation from parents. No significant differences were found in behavioral changes. No serious adverse events occurred in the PACU.</p> Conclusion <p>A novel dexmedetomidine nasal spray improved gastrointestinal recovery and reduced preoperative anxiety and early postoperative pain without compromising safety, suggesting a practical and reproducible sedation strategy for pediatric perioperative care.</p> Trial registration <p>ChiCTR2400088326 Date: August 15, 2024.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A novel dexmedetomidine nasal spray for gastrointestinal recovery in pediatric laparoscopic hernia repair: a randomized controlled trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月18日

查看全文
  • Shimeng Mao,
  • Jinliang Yao,
  • Hongyan He,
  • Mengqin Song,
  • Wenxuan Xiong,
  • Jiying Feng,
  • Ying Wang

摘要

Purpose

Preoperative anxiety is common in pediatric surgical patients and may delay postoperative recovery. Conventional intranasal or nebulized dexmedetomidine often requires off-label dilution and manual assembly, which can lead to dosing inconsistency and variable mucosal absorption. We evaluated a novel dexmedetomidine nasal spray in children undergoing laparoscopic inguinal hernia repair.

Methods

In this study, 100 children aged 2–6 years scheduled for laparoscopic high ligation of the hernia sac for indirect inguinal hernia received either dexmedetomidine spray (Group D, n = 50) or saline (Group C, n = 50) 30 min before anesthesia. Primary outcome was time to first flatus; secondary outcomes included time to first defecation, time to tolerated oral intake, I-FEED scores on postoperative days 1–3, preoperative anxiety in children and parents, postoperative pain, and behavioral changes.

Results

Group D showed significantly shorter time to first flatus (14.61 ± 4.19 h vs. 17.57 ± 5.96 h, P = 0.006), defecation (23.94 ± 7.22 h vs. 29.70 ± 7.63 h, P < 0.001) and time to tolerated oral intake (12.82 ± 5.94 h vs. 14.92 ± 7.02 h, P = 0.047). FLACC scores and I-FEED scores were also lower on day 1 (P = 0.015, P = 0.022, respectively). Intranasal dexmedetomidine attenuates preoperative anxiety in both children and parents and facilitates smoother separation from parents. No significant differences were found in behavioral changes. No serious adverse events occurred in the PACU.

Conclusion

A novel dexmedetomidine nasal spray improved gastrointestinal recovery and reduced preoperative anxiety and early postoperative pain without compromising safety, suggesting a practical and reproducible sedation strategy for pediatric perioperative care.

Trial registration

ChiCTR2400088326 Date: August 15, 2024.